{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T10:10:55Z","timestamp":1793441455271,"version":"4.5.0"},"reference-count":71,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Primary Sj\u00f6gren syndrome (pSS) is a chronic, systemic, autoimmune disorder characterized by lymphocytic infiltrates of the exocrine organs, leading to sicca symptoms and parotid enlargement. pSS has been linked to various neurological manifestations, including peripheral neuropathy (PN). We aimed to provide a comprehensive analysis of the currently available evidence regarding pSS\u2010related PN.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search in the PubMed database was performed, and 49 papers were eligible to be included in this systematic review and meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The pooled prevalence of PN in pSS is estimated to be 15.0% (95% confidence interval\u00a0=\u00a010.7%\u201320.7%). The mean age of pSS patients at PN diagnosis is 59\u2009years. Among the patients with pSS and PN, 83% are females. Neuropathic symptoms usually precede or lead to the pSS diagnosis at a 2:1 ratio in patients with pSS\u2010related PN. The commonest type of pSS\u2010related PN is distal axonal polyneuropathy (80% of patients with pSS\u2010related PN), followed by sensory ganglionopathy. Peripheral and cranial mononeuropathies\u2014particularly trigeminal\u2014are also frequent. Risk factors for developing PN include increasing age and presence of vasculitis. Immune\u2010mediated pathogenetic mechanisms are discussed. Glucocorticoids are the most commonly used treatment option for managing pSS\u2010related PN, when associated with vasculitis, followed by the use of intravenous immunoglobulin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PN is very common in pSS patients. Evidence on long\u2010term prognosis of PN in pSS is limited, and further research is needed. Research into the use of immunosuppressive medication in nonvasculitic neuropathies in the context of pSS merits further consideration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.15555","type":"journal-article","created":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T04:00:11Z","timestamp":1662782411000},"page":"255-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Primary Sj\u00f6gren syndrome\u2010related peripheral neuropathy: A\u00a0systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"30","author":[{"given":"Andreas","family":"Liampas","sequence":"first","affiliation":[{"name":"Medical School University of Cyprus  Nicosia Cyprus"},{"name":"Department of Neurology Nicosia General Hospital  Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Parperis","sequence":"additional","affiliation":[{"name":"Medical School 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