{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:36:08Z","timestamp":1792103768365,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>To evaluate the 1\u2010year effectiveness and tolerability of galcanezumab in real life and the prognostic indicators of persistent response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>High\u2010frequency episodic migraine (HFEM) and chronic migraine (CM) patients treated with galcanezumab who completed a 1\u2010year observation were enrolled. The primary outcomes assessed during the 12\u2009months (V1\u2013V12) were the change in monthly migraine days (MMDs) from baseline and the response rates \u226550% in MMDs (MMD \u226550% RR). The secondary outcomes were changes in pain intensity (numerical rating scale [NRS]) and in monthly acute medication intake (MAMI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 191 patients (77.5% CM). Twenty\u2010three patients (12%) dropped out, two for nonserious adverse events. At least 40% of patients took add\u2010on standard preventives from baseline to V12. At V12, MMDs were reduced by 6.0\u2009days in HFEM and by 11.9\u2009days in CM patients (both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001); NRS and MAMI were also decreased in both groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001). One\u2010hundred eight (56.5%) patients presented MMD \u226550% RR for 9 cumulative months (interquartile range=8): we defined this value as the cutoff for a persistent response. Persistent responders were less likely to have a higher body mass index (BMI) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.007) but more frequently had a good response to triptans (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.005) and MMD \u226550% RR at V1 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0000001). Patients without a persistent response were on add\u2010on therapy for longer periods of time (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Galcanezumab was effective and well\u2010tolerated in the 1\u2010year term, with most patients presenting MMD \u226550% RR for at least 9\u00a0months. Triptan response, lower BMI, and MMD \u226550% RR in the first month emerged as predictive factors for a persistent response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15563","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T07:13:26Z","timestamp":1663053206000},"page":"224-234","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Maintenance of response and predictive factors of 1\u2010year <scp>GalcanezumAb<\/scp> treatment in real\u2010life migraine patients in <scp>Italy<\/scp>: The multicenter prospective cohort <scp>GARLIT<\/scp> study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-9336","authenticated-orcid":false,"given":"Fabrizio","family":"Vernieri","sequence":"first","affiliation":[{"name":"Headache and Neurosonology Unit, Neurology Fondazione Policlinico Campus Bio\u2010Medico  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Brunelli","sequence":"additional","affiliation":[{"name":"Headache and Neurosonology Unit, Neurology Fondazione Policlinico Campus Bio\u2010Medico  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilena","family":"Marcosano","sequence":"additional","affiliation":[{"name":"Headache and Neurosonology Unit, Neurology Fondazione Policlinico Campus Bio\u2010Medico  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Aurilia","sequence":"additional","affiliation":[{"name":"Headache and Pain Unit IRCCS San Raffaele Pisana  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Egeo","sequence":"additional","affiliation":[{"name":"Headache and Pain Unit IRCCS San Raffaele Pisana  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Lovati","sequence":"additional","affiliation":[{"name":"Neurology Unit, Headache Center University Hospital L. 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