{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:46:35Z","timestamp":1788385595493,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with limited treatment options. RNS60 is an immunomodulatory and neuroprotective investigational product that has shown efficacy in animal models of ALS and other neurodegenerative diseases. Its administration has been safe and well tolerated in ALS subjects in previous early phase trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a phase II, multicentre, randomized, double\u2010blind, placebo\u2010controlled, parallel\u2010group trial. Participants diagnosed with definite, probable or probable laboratory\u2010supported ALS were assigned to receive RNS60 or placebo administered for 24\u2009weeks intravenously (375\u2009ml) once a week and via nebulization (4 ml\/day) on non\u2010infusion days, followed by an additional 24\u2009weeks off\u2010treatment. The primary objective was to measure the effects of RNS60 treatment on selected biomarkers of inflammation and neurodegeneration in peripheral blood. Secondary objectives were to measure the effect of RNS60 on functional impairment (ALS Functional Rating Scale\u2014Revised), a measure of self\u2010sufficiency, respiratory function (forced vital capacity, FVC), quality of life (ALS Assessment Questionnaire\u201040, ALSAQ\u201040) and survival. Tolerability and safety were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010four participants were assigned to RNS60 and 73 to placebo. Assessed biomarkers did not differ between arms. The mean rate of decline in FVC and the eating and drinking domain of ALSAQ\u201040 was slower in the RNS60 arm (FVC, difference 0.41 per week, standard error 0.16, <jats:italic>p<\/jats:italic> =\u20090.0101; ALSAQ\u201040, difference \u20130.19 per week, standard error 0.10, <jats:italic>p<\/jats:italic> =\u20090.0319). Adverse events were similar in the two arms. In a <jats:italic>post hoc<\/jats:italic> analysis, neurofilament light chain increased over time in bulbar onset placebo participants whilst remaining stable in those treated with RNS60.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The positive effects of RNS60 on selected measures of respiratory and bulbar function warrant further investigation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15573","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T09:49:49Z","timestamp":1663926589000},"page":"69-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effect of <scp>RNS60<\/scp> in amyotrophic lateral sclerosis: a phase <scp>II<\/scp> multicentre, randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2542-0469","authenticated-orcid":false,"given":"Ettore","family":"Beghi","sequence":"first","affiliation":[{"name":"Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4420-8076","authenticated-orcid":false,"given":"Elisabetta","family":"Pupillo","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Bianchi","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0456-2054","authenticated-orcid":false,"given":"Valentina","family":"Bonetto","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Luotti","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Pasetto","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Bendotti","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Tortarolo","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sironi","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Camporeale","sequence":"additional","affiliation":[{"name":"Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander V.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Neurological Clinical Research Institute Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Paganoni","sequence":"additional","affiliation":[{"name":"Sean M. Healey and AMG Center for ALS at Mass General Hospital Department of Neurology  Boston Massachusetts USA"},{"name":"Spaulding Rehabilitation Hospital Department of PM&amp;R Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Scognamiglio","sequence":"additional","affiliation":[{"name":"ALS Expert Center \u2018Maggiore della Carit\u00e0\u2019 Hospital and University of Piemonte Orientale  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0197-1880","authenticated-orcid":false,"given":"Fabiola","family":"De Marchi","sequence":"additional","affiliation":[{"name":"ALS Expert Center \u2018Maggiore della Carit\u00e0\u2019 Hospital and University of Piemonte Orientale  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Bongioanni","sequence":"additional","affiliation":[{"name":"Spinal Cord Injuries Section Azienda Ospedaliero\u2010Universitaria Pisana  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7504-0379","authenticated-orcid":false,"given":"Renata","family":"Del\u00a0Carratore","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology, CNR\u2010  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Caponnetto","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-6886","authenticated-orcid":false,"given":"Luca","family":"Diamanti","sequence":"additional","affiliation":[{"name":"IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Martinelli","sequence":"additional","affiliation":[{"name":"IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5122-7243","authenticated-orcid":false,"given":"Andrea","family":"Calvo","sequence":"additional","affiliation":[{"name":"Centro Regionale Esperto per la Sclerosi Laterale Amiotrofica Dipartimento di Neuroscienze \u2018Rita Levi Montalcini\u2019 Universit\u00e0 degli Studi di Torino AOU Citt\u00e0 della Salute e della Scienza di Torino  Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2852-7512","authenticated-orcid":false,"given":"Massimiliano","family":"Filosto","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences University of Brescia  Gussago Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Padovani","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences University of Brescia  Gussago Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano\u00a0Cotti","family":"Piccinelli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Sciences University of Brescia  Gussago Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Neurological Sciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Dalla Giacoma","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Neurological Sciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"De\u00a0Angelis","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Neurological Sciences University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Inghilleri","sequence":"additional","affiliation":[{"name":"Universit\u00e0 di Roma \u2018Sapienza\u2019 UOSD Malattie Neurodegenerative Centro Malattie Rare Neuromuscolari Policlinico Universitario Umberto I  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8910-3131","authenticated-orcid":false,"given":"Rossella","family":"Spataro","sequence":"additional","affiliation":[{"name":"ALS Clinical Research Center AOUP \u2018P Giaccone\u2019 \u2010 University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2045-1864","authenticated-orcid":false,"given":"Vincenzo","family":"La\u00a0Bella","sequence":"additional","affiliation":[{"name":"ALS Clinical Research Center AOUP \u2018P Giaccone\u2019 \u2010 University of Palermo  Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Logroscino","sequence":"additional","affiliation":[{"name":"Center for neurodegenerative diseases and the Aging Brain Department of Clinical Research in Neurology of the University of Bari at \u2018Pia Fondazione Card G. Panico \u2018Hospital Tricase  Tricase Italy"},{"name":"Department of Basic Medicine Neuroscience and Sense Organs University Aldo Moro Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lunetta","sequence":"additional","affiliation":[{"name":"Centro Clinico NeMO Milano Fondazione Serena ONLUS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Tarlarini","sequence":"additional","affiliation":[{"name":"Centro Clinico NeMO Milano Fondazione Serena ONLUS  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Mandrioli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Metabolic and Neural Sciences University of Modena and Reggio Emilia  Modena Italy"},{"name":"Department of Neurosciences Azienda Ospedaliero\u2010Universitaria Di Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2566-3671","authenticated-orcid":false,"given":"Ilaria","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Azienda Ospedaliero\u2010Universitaria Di Modena  Modena Italy"},{"name":"Clinical and Experimental Medicine PhD Program University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Simonini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Azienda Ospedaliero\u2010Universitaria Di Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Zucchi","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Azienda Ospedaliero\u2010Universitaria Di Modena  Modena Italy"},{"name":"Neuroscience PhD Program University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Monsurr\u00f2","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u2018Luigi Vanvitelli\u2019  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4862-4165","authenticated-orcid":false,"given":"Dario","family":"Ricciardi","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u2018Luigi Vanvitelli\u2019  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Trojsi","sequence":"additional","affiliation":[{"name":"Department of Advanced Medical and Surgical Sciences University of Campania \u2018Luigi Vanvitelli\u2019  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0513-9517","authenticated-orcid":false,"given":"Nilo","family":"Riva","sequence":"additional","affiliation":[{"name":"Neurology Unit Neurorehabilitation Unit, and Neurophysiology Unit Vita\u2010Salute San Raffaele University and San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5485-0479","authenticated-orcid":false,"given":"Massimo","family":"Filippi","sequence":"additional","affiliation":[{"name":"Neurology Unit Neurorehabilitation Unit, and Neurophysiology Unit Vita\u2010Salute San Raffaele University and San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7429-3091","authenticated-orcid":false,"given":"Isabella Laura","family":"Simone","sequence":"additional","affiliation":[{"name":"Neurology Unit Department of Basic Medical Sciences Neurosciences and Sense Organs University of Bari  Bari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9691-6328","authenticated-orcid":false,"given":"Gianni","family":"Sorar\u00f9","sequence":"additional","affiliation":[{"name":"Motor Neuton Disease Center Department of Neurosciences Azienda Ospedale Universit\u00e0 di Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Spera","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera \u2018S Maria\u2019 Terni  Terni Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Florio","sequence":"additional","affiliation":[{"name":"Neurology Department Fondazione IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Siciliano","sequence":"additional","affiliation":[{"name":"Department of clinical and experimental medicine University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Conte","sequence":"additional","affiliation":[{"name":"Centro Clinico NEMO\u2010Fondazione Policlinico Universitario A. Gemelli IRCCS  Roma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Valeria","family":"Saddi","sequence":"additional","affiliation":[{"name":"Neurology Department San Francesco Hospital  Nuoro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Carboni","sequence":"additional","affiliation":[{"name":"Neurology Department San Francesco Hospital  Nuoro Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Mazzini","sequence":"additional","affiliation":[{"name":"ALS Expert Center \u2018Maggiore della Carit\u00e0\u2019 Hospital and University of Piemonte Orientale  Novara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the RNS60\u2010ALS Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986707782793862"},{"issue":"3","key":"e_1_2_11_3_1","first-page":"CD001447","article-title":"Riluzole for amyotrophic lateral sclerosis (ALS)\/motor neuron disease (MND)","volume":"2012","author":"Miller RG","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30115-1"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.06.027"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00679"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcz009"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology8020036"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1101-0"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-013-9503-3"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113279"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-017-2214-z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30020"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-017-9771-4"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103606"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051869"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25248"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26385"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab333"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.04.018"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-020-00406-3"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2017.1353098"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194316.91908.8a"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2010.01333.x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201201544"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413111200"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2009.2548"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025545"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00099"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.104815"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20376"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.637"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02560.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2010.03.004"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009559"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1600251113"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2003715"},{"key":"e_1_2_11_39_1","unstructured":"MillerT CudkowiczM.In American Neurological Association Annual Meeting (Virtual 2021 Oct 17\u201319)."},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-022-01237-4"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25661"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15573","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.15573","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T13:18:30Z","timestamp":1692537510000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.15573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,7]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/ene.15573"],"URL":"https:\/\/doi.org\/10.1111\/ene.15573","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,7]]},"assertion":[{"value":"2022-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}