{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:32:19Z","timestamp":1783477939800,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002619","name":"Ajou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Parkinson's disease (PD) with glucocerebrosidase (<jats:italic>GBA<\/jats:italic>) gene mutation (GBA\u2010PD) is known to show more rapid clinical progression than sporadic PD without <jats:italic>GBA<\/jats:italic> mutation (sPD). This study was performed to delineate the specific patterns of cortical hypoperfusion, dopamine transporter uptake and cardiac meta\u2010iodobenzylguanidine (MIBG) uptake of GBA\u2010PD in comparison to sPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Through next\u2010generation sequencing analysis targeting 41 genes, a total of 16 GBA\u2010PD and 24 sPD patients (sex, age matched) were enrolled in the study, and the clinical, dual\u2010phase [<jats:sup>18<\/jats:sup>F]\u2010<jats:italic>N<\/jats:italic>\u2010(3\u2010fluoropropyl)\u20102\u03b2\u2010carboxymethoxy\u20103\u03b2\u2010(4\u2010iodophenyl) nortropane (<jats:sup>1<\/jats:sup><jats:sup>8<\/jats:sup>F\u2010FP\u2010CIT) positron emission tomography (PET)\u00a0and cardiac <jats:sup>123<\/jats:sup>I\u2010MIBG scintigraphy results were compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The GBA\u2010PD group had higher rates of rapid eye movement sleep behavior disorder, orthostatic hypotension and neuropsychiatric symptoms than the sPD group. Early\u2010phase <jats:sup>18<\/jats:sup>F\u2010FP\u2010CIT PET\u00a0showed significantly lower standard uptake value ratio on bilateral posterior parietal cortex (0.94\u2009\u00b1\u20090.05 vs. 1.02\u2009\u00b1\u20090.04, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.011) and part of the occipital cortex (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) in the GBA\u2010PD group than the sPD group. In striatal dopamine transporter uptake, the regional standard uptake value ratio, asymmetry index and caudate\u2010to\u2010putamen ratio were similar between the two groups. The GBA\u2010PD group had a lower heart\u2010to\u2010mediastinum uptake ratio in <jats:sup>123<\/jats:sup>I\u2010MIBG scintigraphy than the sPD group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The GBA\u2010PD patients showed decreased regional perfusion in the bilateral posterior parietal and occipital cortex. Cardiac sympathetic denervation and non\u2010motor symptoms (orthostatic hypotension, rapid eye movement sleep behavior disorder) were more common in GBA\u2010PD than sPD. These findings suggest that GBA\u2010PD patients have more widespread peripheral (extranigral) \u03b1\u2010synuclein accumulation, representing a body\u2010first PD subtype.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15615","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T18:20:31Z","timestamp":1666808431000},"page":"344-352","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dual\u2010phase <sup>18<\/sup>F\u2010FP\u2010CIT positron emission tomography and cardiac <sup>123<\/sup>I\u2010MIBG scintigraphy of Parkinson's disease patients with <i>GBA<\/i> mutations: evidence of the body\u2010first type?"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4397-6612","authenticated-orcid":false,"given":"Min Seung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology, Parkinson Center Ajou University School of Medicine  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