{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T19:51:28Z","timestamp":1771962688465,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011963","name":"European Academy of Neurology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The aim of this study was to assess the neurological complications of SARS\u2010CoV\u20102 infection and compare phenotypes and outcomes in infected patients with and without selected neurological manifestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data source was a registry established by the European Academy of Neurology during the first wave of the COVID\u201019 pandemic. Neurologists collected data on patients with COVID\u201019 seen as in\u2010 and outpatients and in emergency rooms in 23 European and seven non\u2010European countries. Prospective and retrospective data included patient demographics, lifestyle habits, comorbidities, main COVID\u201019 complications, hospital and intensive care unit admissions, diagnostic tests, and outcome. Acute\/subacute selected neurological manifestations in patients with COVID\u201019 were analysed, comparing individuals with and without each condition for several risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>By July 31, 2021, 1523 patients (758 men, 756 women, and nine intersex\/unknown, aged 16\u2013101\u2009years) were registered. Neurological manifestations were diagnosed in 1213 infected patients (79.6%). At study entry, 978 patients (64.2%) had one or more chronic general or neurological comorbidities. Predominant acute\/subacute neurological manifestations were cognitive dysfunction (<jats:italic>N<\/jats:italic>\u00a0=\u00a0449, 29.5%), stroke (<jats:italic>N<\/jats:italic>\u00a0=\u00a0392, 25.7%), sleep\u2013wake disturbances (<jats:italic>N<\/jats:italic>\u00a0=\u00a0250, 16.4%), dysautonomia (<jats:italic>N<\/jats:italic>\u00a0=\u00a0224, 14.7%), peripheral neuropathy (<jats:italic>N<\/jats:italic>\u00a0=\u00a0145, 9.5%), movement disorders (<jats:italic>N<\/jats:italic>\u00a0=\u00a0142, 9.3%), ataxia (<jats:italic>N<\/jats:italic>\u00a0=\u00a0134, 8.8%), and seizures (<jats:italic>N<\/jats:italic>\u00a0=\u00a0126, 8.3%). These manifestations tended to differ with regard to age, general and neurological comorbidities, infection severity and non\u2010neurological manifestations, extent of association with other acute\/subacute neurological manifestations, and outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with COVID\u201019 and neurological manifestations present with distinct phenotypes. Differences in age, general and neurological comorbidities, and infection severity characterize the various neurological manifestations of COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15617","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T10:34:10Z","timestamp":1667212450000},"page":"413-433","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Comparative features and outcomes of major neurological complications of <scp>COVID<\/scp>\u201019"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2542-0469","authenticated-orcid":false,"given":"Ettore","family":"Beghi","sequence":"first","affiliation":[{"name":"Istituto di Ricerche Farmacologiche Mario Negri IRCCS  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7968-5908","authenticated-orcid":false,"given":"Elena","family":"Moro","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire de Grenoble, Service de Neurologie, Grenoble Institute of Neurosciences Grenoble Alpes University  Grenoble France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6862-5515","authenticated-orcid":false,"given":"Eugenia Irene","family":"Davidescu","sequence":"additional","affiliation":[{"name":"Neurology Department, Colentina Clinical Hospital, Bucharest, Romania and Department of Clinical Neurosciences \u201cCarol Davila\u201d University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan\u00a0Ovidiu","family":"Popescu","sequence":"additional","affiliation":[{"name":"Neurology Department, Colentina Clinical Hospital, Bucharest, Romania and Department of Clinical Neurosciences \u201cCarol Davila\u201d University of Medicine and Pharmacy  Bucharest Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oxana","family":"Grosu","sequence":"additional","affiliation":[{"name":"Diomid Gherman Institute of Neurology and Neurosurgery  Chi\u0219in\u0103u Moldova"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Valzania","sequence":"additional","affiliation":[{"name":"Neurology Unit, Neuromotor and Rehabilitation Department Azienda USL\u2010IRCCS di Reggio Emilia  Reggio Emilia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Sofia","family":"Cotelli","sequence":"additional","affiliation":[{"name":"Neurology Unit ASST Valcamonica  Brescia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordana","family":"Kiteva\u2010Trenchevska","sequence":"additional","affiliation":[{"name":"University Clinic for Neurology, Medical Faculty University \"Ss. 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