{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T19:49:28Z","timestamp":1776541768418,"version":"3.51.2"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T00:00:00Z","timestamp":1669507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>In addition to combined central and peripheral demyelination, other immune diseases could involve both the central nervous system (CNS) and peripheral nervous system (PNS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To identify immune\u2010mediated diseases responsible for symptomatic combined central\/peripheral nervous system involvement (ICCPs), we conducted a multicentric retrospective study and assessed clinical, electrophysiological, and radiological features of patients fulfilling our ICCP criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients (20 males) were included and followed during a median of 79.5\u00a0months (interquartile range [IQR]\u00a0=\u00a043\u2013145). The median age at onset was 51.5\u2009years (IQR\u00a0=\u00a039\u201358). Patients were assigned to one of four groups: (i) monophasic disease with concomitant CNS\/PNS involvement including anti\u2010GQ1b syndrome (acute polyradiculoneuropathy\u2009+\u2009rhombencephalitis,<jats:italic>n<\/jats:italic>\u00a0=\u20092), checkpoint inhibitor\u2010related toxicities (acute polyradiculoneuropathy\u2009+\u2009encephalitis,<jats:italic>n<\/jats:italic>\u00a0=\u20093), and anti\u2010glial fibrillary acidic protein astrocytopathy (subacute polyradiculoneuropathy and meningoencephalomyelitis with linear gadolinium enhancements,<jats:italic>n<\/jats:italic>\u00a0=\u20092); (ii) chronic course with concomitant CNS\/PNS involvement including paraneoplastic syndromes (ganglionopathy\/peripheral hyperexcitability\u2009+\u2009limbic encephalitis,<jats:italic>n<\/jats:italic>\u00a0=\u20094); (iii) chronic course with sequential CNS\/PNS involvement including POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes) syndrome (polyradiculoneuropathy\u2009+\u2009strokes,<jats:italic>n<\/jats:italic>\u00a0=\u20092), histiocytosis (polyradiculoneuropathy\u2009+\u2009lepto\u2010\/pachymeningitis,<jats:italic>n<\/jats:italic>\u00a0=\u20091), and systemic vasculitis (multineuropathy\u2009+\u00a0CNS vasculitis\/pachymeningitis,<jats:italic>n<\/jats:italic>\u00a0=\u20092); and (iv) chronic course with concomitant or sequential CNS\/PNS involvement including combined central and peripheral demyelination (polyradiculoneuropathy\u2009+\u00a0CNS demyelinating lesions,<jats:italic>n<\/jats:italic>\u00a0=\u200910) and connective tissue diseases (ganglionopathy\/radiculopathy\/multineuropathy\u2009+\u2009limbic encephalitis\/transverse myelitis\/stroke,<jats:italic>n<\/jats:italic>\u00a0=\u20094).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We diagnosed nine ICCPs. The timing of central and peripheral manifestations and the disease course help determine the underlying immune disease. When antibody against neuroglial antigen is identified, CNS and PNS involvement is systematically concomitant, suggesting a common CNS\/PNS antigen and a simultaneous disruption of blood\u2013nerve and blood\u2013brain barriers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15628","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T08:04:06Z","timestamp":1668153846000},"page":"490-500","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Immune\u2010mediated diseases involving central and peripheral nervous systems"],"prefix":"10.1111","volume":"30","author":[{"given":"Aurelie","family":"Leboyan","sequence":"first","affiliation":[{"name":"Department of Neurology Gui de Chauliac University Hospital Center Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Esselin","sequence":"additional","affiliation":[{"name":"Department of Neurology Gui de Chauliac University Hospital Center Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Laure","family":"Bascou","sequence":"additional","affiliation":[{"name":"Clinical Research and Epidemiology Unit, University Hospital Center University of Montpellier Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Duflos","sequence":"additional","affiliation":[{"name":"Clinical Research and Epidemiology Unit, University Hospital Center University of Montpellier Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioana","family":"Ion","sequence":"additional","affiliation":[{"name":"Department of Neurology Caremeau University Hospital Center N\u00eemes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud","family":"Charif","sequence":"additional","affiliation":[{"name":"Department of Neurology Gui de Chauliac University Hospital Center Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Castelnovo","sequence":"additional","affiliation":[{"name":"Department of Neurology Caremeau University Hospital Center N\u00eemes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0985-3662","authenticated-orcid":false,"given":"Clarisse","family":"Carra\u2010Dalliere","sequence":"additional","affiliation":[{"name":"Department of Neurology Gui de Chauliac University Hospital Center Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Ayrignac","sequence":"additional","affiliation":[{"name":"Department of Neurology Gui de Chauliac University Hospital Center Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Kerschen","sequence":"additional","affiliation":[{"name":"Department of Neurology Luxembourg Hospital Center Luxembourg City Luxembourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Chbicheb","sequence":"additional","affiliation":[{"name":"Department of Neurology Narbonne Hospital Center Narbonne France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludovic","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Neurology Perpignan Hospital Center Perpignan France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre T. J.","family":"Maria","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Saint Eloi University Hospital Center Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Guilpain","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Saint Eloi University Hospital Center Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Carriere","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Gui de Chauliac University Hospital Center Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas\u00a0Menjot","family":"de Champfleur","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Gui de Chauliac University Hospital Center Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Vincent","sequence":"additional","affiliation":[{"name":"Department of Immunology Saint Eloi University Hospital Center Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Jentzer","sequence":"additional","affiliation":[{"name":"Department of Immunology Saint Eloi University Hospital Center Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Labauge","sequence":"additional","affiliation":[{"name":"Department of Neurology Gui de Chauliac University Hospital Center Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me J.","family":"Devaux","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, National Center for Scientific Research UMR5203 Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6940-8926","authenticated-orcid":false,"given":"Guillaume","family":"Taieb","sequence":"additional","affiliation":[{"name":"Department of Neurology Gui de Chauliac University Hospital Center Montpellier France"},{"name":"Institute of Functional Genomics, National Center for Scientific Research UMR5203 Montpellier France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2006.108290"},{"key":"e_1_2_9_3_1","first-page":"29","article-title":"A nationwide survey of combined central and peripheral demyelination in Japan","volume":"87","author":"Ogata H","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.02.022"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002825"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001729"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-013-6918-y"},{"issue":"6","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"e1093","DOI":"10.1212\/NXI.0000000000001093","article-title":"Primary Angiitis of the CNS: a systematic review and meta\u2010analysis","volume":"8","author":"Beuker C","year":"2021","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-015-1629-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg233"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-306410"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp136"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-008-0009-y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24632"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-307815"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns.12455"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24802"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.10.003"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-690636"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24881"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2003.034447"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203312460722"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-019-03273-1"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-318957"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020001865"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011795"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-021-01581-0"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00430"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756286420985323"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01146"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2018.02.006"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000503"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000924"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102718"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a1aa9c"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00899-1"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.05.012"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.01.014"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30471-4"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001032"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15628","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.15628","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T17:10:52Z","timestamp":1701364252000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.15628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,27]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1111\/ene.15628"],"URL":"https:\/\/doi.org\/10.1111\/ene.15628","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,27]]},"assertion":[{"value":"2022-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}