{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:59:32Z","timestamp":1780545572067,"version":"3.54.1"},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,3]],"date-time":"2022-12-03T00:00:00Z","timestamp":1670025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARG\u201016\u2010442861"],"award-info":[{"award-number":["AARG\u201016\u2010442861"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000965","name":"American Federation for Aging Research","doi-asserted-by":"publisher","award":["RAG11482"],"award-info":[{"award-number":["RAG11482"]}],"id":[{"id":"10.13039\/100000965","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Stroke and small vessel disease cause gait disturbances and falls. The naturally occurring loss\u2010of\u2010function mutation in the C\u2010C chemokine receptor 5 gene (<jats:italic>CCR5<\/jats:italic>\u2010\u039432) has recently been reported as a protective factor in post\u2010stroke motor and cognitive recovery. We sought to examine whether it also influences gait and balance measures up to 2\u2009years after stroke.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Participants were 575 survivors of first\u2010ever, mild\u2013moderate ischaemic stroke or transient ischaemic attack from the TABASCO prospective study, who underwent a 3\u00a0T magnetic resonance imaging at baseline and were examined by a multi\u2010professional team 6, 12 and 24\u2009months after the event, using neurological, neuropsychological and mobility examinations. Gait rhythm and the timing of the gait cycle were measured by force\u2010sensitive insoles.<jats:italic>CCR5<\/jats:italic>\u2010\u039432 status and gait measures were available for 335 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>CCR5<\/jats:italic>\u2010\u039432 carriers (16.4%) had higher gait speed and decreased (better) stride and swing time variability 6 and 12\u2009months after the index event compared to non\u2010carriers (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01 for all). The association remained significant after adjustment for age, gender, education, ethnicity and stroke severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Significant associations were found between gait measurements and<jats:italic>CCR5<\/jats:italic>\u2010\u039432 loss\u2010of\u2010function mutation amongst stroke survivors. This is the first study showing that genetic predisposition may predict long\u2010term gait function after ischaemic stroke.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15637","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T07:41:33Z","timestamp":1668584493000},"page":"692-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp><i>CCR5<\/i>\u2010\u039432<\/scp>polymorphism\u2014a possible protective factor from gait impairment amongst post\u2010stroke patients"],"prefix":"10.1111","volume":"30","author":[{"given":"Jeremy","family":"Molad","sequence":"first","affiliation":[{"name":"Department of Neurology Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hen","family":"Hallevi","sequence":"additional","affiliation":[{"name":"Department of Neurology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Department of Neurology, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Seyman","sequence":"additional","affiliation":[{"name":"Department of Neurology Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Rotschild","sequence":"additional","affiliation":[{"name":"Department of Neurology Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natan M.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Brain Center Shaare Zedek Medical Center Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Tene","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Department of Psychiatry, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1482-8522","authenticated-orcid":false,"given":"Nir","family":"Giladi","sequence":"additional","affiliation":[{"name":"Department of Neurology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Department of Neurology, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Department of Physical Therapy, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Hausdorff","sequence":"additional","affiliation":[{"name":"Department of Neurology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Department of Physical Therapy, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University Tel Aviv Israel"},{"name":"Rush Alzheimer's Disease Center and Department of Orthopedic Surgery Rush University Medical Center Chicago Illinois USA"},{"name":"Center for the Study of Movement, Cognition, and Mobility, Neurological Institute Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Mirelman","sequence":"additional","affiliation":[{"name":"Department of Neurology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Department of Neurology, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"},{"name":"Sagol School of Neuroscience Tel Aviv University Tel Aviv Israel"},{"name":"Center for the Study of Movement, Cognition, and Mobility, Neurological Institute Tel Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1645-8246","authenticated-orcid":false,"given":"Einor","family":"Ben Assayag","sequence":"additional","affiliation":[{"name":"Department of Neurology Tel Aviv Sourasky Medical Center Tel Aviv Israel"},{"name":"Department of Neurology, Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2001.24893"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/62.9.983"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2001.49274.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humov.2007.05.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2008.10.061"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20985"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.044"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2011.00652.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.7.864"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329170002691X"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0753-3322(97)82328-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22554"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-2-19"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007346"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01616.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2340\/1650197719952736","article-title":"The balance scale: reliability assessment with elderly residents and patients with an acute stroke","volume":"27","author":"Berg K","year":"1995","journal-title":"Scand J Rehabil Med"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130310"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-002-1354-8"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2013.04.011"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20452"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/153331750602100105"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.14m09759"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190339"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363690"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/s21196543"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2015.08.017"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glx187"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2020.04.009"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glab269"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020441"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.159"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gls191"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.200197"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-0052-6"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800587"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20934"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2020.7015"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000951"},{"issue":"6","key":"e_1_2_10_41_1","first-page":"571","article-title":"Treatment intensification with Maraviroc (CCR5 antagonist) leads to declines in CD16\u2010expressing monocytes in cART\u2010suppressed chronic HIV\u2010infected subjects and is associated with improvements in neurocognitive test performance: implications for HIV\u2010associated neurocognitive disease (HAND)","volume":"20","author":"Ndhlovu LC","year":"2014","journal-title":"J Neuroyirol"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/23969873221098857"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.3.399"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1086\/301867"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1089\/109065703322783716"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15637","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.15637","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15637","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T08:31:14Z","timestamp":1728376274000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.15637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,3]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1111\/ene.15637"],"URL":"https:\/\/doi.org\/10.1111\/ene.15637","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,3]]},"assertion":[{"value":"2022-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}