{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:24:31Z","timestamp":1779909871985,"version":"3.53.1"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T00:00:00Z","timestamp":1670716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>This study aimed at estimating the prevalence of language impairment (LI) in a large, clinic\u2010based cohort of non\u2010demented amyotrophic lateral sclerosis (ALS) patients and assessing its underpinnings at motor and non\u2010motor levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Non\u2010demented ALS patients (<jats:italic>N<\/jats:italic>\u00a0=\u00a0348) underwent the Edinburgh Cognitive and Behavioural ALS Screen (ECAS), as well as an assessment of behavioural\/psychiatric and motor\u2010functional features. The prevalence of LI was estimated based on the proportion of patients showing a performance below the age\u2010 and education\u2010adjusted cut\u2010off on the ECAS\u2010Language. Multiple regression models were run to assess the determinants of language functioning and impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of LI was 22.7%. 46.6% of the variance of ECAS\u2010Language scores remained unexplained, with only the ECAS\u2010Executive positively predicting them (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; <jats:italic>\u03b7<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00.07). Similarly, only a lower score on the ECAS\u2010Executive predicted a higher probability of a below cut\u2010off ECAS\u2010Language performance (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Spelling and Naming tasks were the major drivers of ECAS\u2010Language performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study suggests that, in non\u2010demented ALS patients, LI occurs in \u224823% of cases, is significantly driven by executive dysfunction but, at the same time, partially independent of it and is not associated with other motor or non\u2010motor features.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15652","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T13:10:03Z","timestamp":1669727403000},"page":"606-611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence and determinants of language impairment in non\u2010demented amyotrophic lateral sclerosis patients"],"prefix":"10.1111","volume":"30","author":[{"given":"Federica","family":"Solca","sequence":"first","affiliation":[{"name":"Department of Neurology and 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