{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:56:39Z","timestamp":1766138199944,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T00:00:00Z","timestamp":1674518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Response predictors to erenumab (ERE) in migraine patients would benefit their clinical management. We investigate associations between patients' clinical characteristics and polymorphisms at calcitonin receptor\u2010like receptor (<jats:italic>CALCRL<\/jats:italic>) and receptor activity\u2010modifying protein 1 (<jats:italic>RAMP1<\/jats:italic>) genes and response to ERE treatment measured as clinically meaningful improvement on the Headache Impact Test\u20106 (HIT\u20106) score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This post hoc analysis of a prospective, multicenter, investigator\u2010initiated study involves 110 migraine patients starting ERE 70\u2009mg\/month. Demographics, medical history, and migraine\u2010related burden measured by HIT\u20106 score were collected during 3\u00a0months before and after ERE start. Selected polymorphic variants of<jats:italic>CALCRL<\/jats:italic>and<jats:italic>RAMP1<\/jats:italic>genes were determined using real\u2010time polymerase chain reaction. Logistic regression models identified independent predictors for response to ERE, defined as HIT\u20106 score improvement \u2265\u20098 points (HIT\u20106 responders [HIT\u20106 RESP] vs. HIT\u20106 nonresponders).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At Month 3, 58 (52.7%) patients were HIT\u20106 RESP. Comorbid hypertension predicted a lower probability of being HIT\u20106 RESP (odds ratio [OR] =\u20090.160, 95% confidence interval [CI] =\u20090.047\u20130.548,<jats:italic>p<\/jats:italic>\u00a0=\u20090.003). Compared to major alleles, minor alleles<jats:italic>CALCRL<\/jats:italic>rs6710852G and<jats:italic>RAMP<\/jats:italic>rs6431564G conferred an increased probability of being HIT\u20106 RESP (for each G allele: OR\u00a0=\u00a02.82, 95% CI\u00a0=\u00a01.03\u20137.73,<jats:italic>p<\/jats:italic>\u00a0=\u20090.043; OR\u00a0=\u00a02.10, 95% CI\u00a0=\u00a01.05\u20134.22,<jats:italic>p<\/jats:italic>\u00a0=\u20090.037).<jats:italic>RAMP1<\/jats:italic>rs13386048A and<jats:italic>RAMP1<\/jats:italic>rs12465864G decreased this probability (for each rs13386048A, OR\u00a0=\u00a00.53, 95% CI\u00a0=\u00a00.28\u20130.98,<jats:italic>p<\/jats:italic>\u00a0=\u20090.042; for each rs12465864G, OR\u00a0=\u00a00.32, 95% CI\u00a0=\u00a00.13\u20130.75,<jats:italic>p<\/jats:italic>\u00a0=\u20090.009). A genetic risk score based on the presence and number of identified risk alleles was independently associated with HIT\u20106 RESP (OR\u00a0=\u00a00.49, 95% CI\u00a0=\u00a00.33\u20130.72,<jats:italic>p<\/jats:italic>\u00a0=\u20090.0003), surviving Bonferroni correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Response to ERE was associated with comorbid hypertension and specific allelic variants in<jats:italic>CALCRL<\/jats:italic>and<jats:italic>RAMP1<\/jats:italic>genes. Results require confirmation in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15678","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T03:53:43Z","timestamp":1673409223000},"page":"1099-1108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Response to erenumab assessed by Headache Impact Test\u20106 is modulated by genetic factors and arterial hypertension: An explorative cohort study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9990-3431","authenticated-orcid":false,"given":"Chiara","family":"Zecca","sequence":"first","affiliation":[{"name":"Department of Neurology, Neurocenter of Southern Switzerland Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale Lugano Switzerland"},{"name":"Faculty of Biomedical Sciences Universit\u00e0 della Svizzera Italiana Lugano Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Terrazzino","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Interdepartmental Research Center of Pharmacogenetics and Pharmacogenomics University of Piemonte Orientale \"A. Avogadro\" Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Para","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurocenter of Southern Switzerland Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale Lugano Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Campagna","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurocenter of Southern Switzerland Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale Lugano Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4356-8109","authenticated-orcid":false,"given":"Michele","family":"Viana","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurocenter of Southern Switzerland Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale Lugano Switzerland"},{"name":"Headache Group, Department of Basic and Clinical Neurosciences King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph J.","family":"Schankin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital Bern University Hospital, University of Bern Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7554-0664","authenticated-orcid":false,"given":"Claudio","family":"Gobbi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Neurocenter of Southern Switzerland Ospedale Regionale di Lugano, Ente Ospedaliero Cantonale Lugano Switzerland"},{"name":"Faculty of Biomedical Sciences Universit\u00e0 della Svizzera Italiana Lugano Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30499-X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0621-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14070700"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01335-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14032"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102418759786"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1705848"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32534-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30083-2"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30478-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-020-01157-8"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13701"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4137\/HSI.S11093"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1026119331193"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15236"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102412449933"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.7.1.19"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-021-00990-0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-021-01295-7"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003348"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.163"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.62"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14194"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14051"},{"key":"e_1_2_8_27_1","unstructured":"U.S. Food and Drug Administration.https:\/\/www.accessdata.fda.gov\/scripts\/cder\/safetylabelingchanges\/index.cfm?event=searchdetail.page&DrugNameID=1894#. 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