{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:23:29Z","timestamp":1792621409688,"version":"4.5.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,12]],"date-time":"2023-02-12T00:00:00Z","timestamp":1676160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Tremor in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is underrecognized, and the pathophysiology remains incompletely understood. This study evaluated tremor in CIDP and tested the hypothesis, established in other demyelinating neuropathies, that tremor occurs due to mistimed peripheral inputs affecting central motor processing. Additionally, the tremor stability index (TSI) was calculated with the hypothesis that CIDP\u2010related tremor is more variable than other tremor disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with typical CIDP were prospectively recruited from neuromuscular clinics. Alternative causes of neuropathy and tremor were excluded. Cross\u2010sectional clinical assessment and extensive tremor study recordings were undertaken. Pearson correlation coefficient was used to compare nerve conduction studies and tremor characteristics, and <jats:italic>t<\/jats:italic>\u2010test was used for comparisons between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients with CIDP were included. Upper limb postural and action tremor was present in 66% and was mild according to the Essential Tremor Rating Assessment Scale. Tremor did not significantly impact disability. Surface electromyography (EMG) found high\u2010frequency spectral peaks in deltoid (13.73\u2009\u00b1\u20090.66\u2009Hz), biceps brachii (11.82\u2009\u00b1\u20090.91\u2009Hz), and extensor carpi radialis (11.87\u2009\u00b1\u20090.91\u2009Hz) muscles, with lower peaks in abductor pollicis brevis EMG (6.07\u2009\u00b1\u20090.45\u2009Hz) and index finger accelerometry (6.53\u2009\u00b1\u20090.42\u2009Hz). Tremor was unchanged by weight loading but correlated with ulnar nerve F\u2010wave latency and median nerve sensory amplitude. TSI (2.3\u00a0\u00b1\u20090.1) was significantly higher than essential tremor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Postural tremor is a common feature in CIDP. Tremor was unaffected by weight loading, typical of centrally generated tremors, although there was a correlation with peripheral nerve abnormalities. The high beat\u2010to\u2010beat variability on TSI and gradation of peak frequencies further suggest a complex pathophysiology. These findings may assist clinicians with the diagnosis of neuropathic tremor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15693","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T13:34:55Z","timestamp":1674567295000},"page":"1059-1068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Chronic inflammatory demyelinating polyradiculoneuropathy\u2010associated tremor: Phenotype and pathogenesis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7249-210X","authenticated-orcid":false,"given":"Matthew","family":"Silsby","sequence":"first","affiliation":[{"name":"Neurology Department Westmead Hospital  Sydney New South Wales Australia"},{"name":"Westmead Clinical School University of Sydney  Sydney New South Wales Australia"},{"name":"Brain and Nerve Research Centre University of Sydney  Sydney New South Wales Australia"},{"name":"Neurology Department Concord Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro F.","family":"Fois","sequence":"additional","affiliation":[{"name":"Neurology Department Westmead Hospital  Sydney New South Wales Australia"},{"name":"Westmead Clinical School University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Con","family":"Yiannikas","sequence":"additional","affiliation":[{"name":"Neurology Department Concord Hospital  Sydney New South Wales Australia"},{"name":"Neurology Department Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Ng","sequence":"additional","affiliation":[{"name":"Neurology Department Royal North Shore Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9054-026X","authenticated-orcid":false,"given":"Matthew C.","family":"Kiernan","sequence":"additional","affiliation":[{"name":"Neurology Department Royal Prince Alfred Hospital  Sydney New South Wales Australia"},{"name":"Brain and Mind Research Centre University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3085-2282","authenticated-orcid":false,"given":"Victor S. 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