{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:33:07Z","timestamp":1773297187365,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T00:00:00Z","timestamp":1675555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Sexual dysfunction (SD) in people with multiple sclerosis (pwMS) is common and an often underestimated issue in the care of pwMS. The objective of the study was to evaluate risk factors for SD in pwMS, correlate its prevalence with patient\u2010reported measures (quality of life and physical activity) and analyse its association with hormonal status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sexual dysfunction was determined in 152 pwMS using the Multiple Sclerosis Intimacy and Sexuality Questionnaire 19. A logistical regression model was used to identify independent risk factors for SD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of SD in pwMS was 47%. Independent risk factors for the development of SD were ever\u2010smoking (odds ratio [OR] 3.4, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.023), disability as measured by the Expanded Disability Status Scale (OR 2.0, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), depression (OR 4.3, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.047) and bladder and bowel dysfunction (OR 8.8, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001); the use of disease\u2010modifying treatment was associated with a lower risk for SD (OR 0.32, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.043). SD was associated with worse quality of life (Multiple Sclerosis Impact Scale 29: physical score 6.3 vs. 40.0; psychological score 8.3 vs. 33.3; both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and lower physical activity (Baecke questionnaire, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Laboratory analysis revealed significantly higher luteinizing hormone and follicle\u2010stimulating hormone levels and lower 17\u2010beta oestradiol, androstenedione, dehydroepiandrosterone sulfate, oestrone and anti\u2010Mullerian hormone levels in female pwMS with SD. In male pwMS and SD, there was a significant decrease in inhibin B levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings highlight the requirement of a holistic approach to SD in MS including physical, neurourological and psychosocial factors. Active screening for SD, especially in patients with disability, depression or bladder and bowel dysfunction, is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15696","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T04:55:00Z","timestamp":1674622500000},"page":"991-1000","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sexual dysfunction in female and male people with multiple sclerosis: disability, depression and hormonal status matter"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6183-2394","authenticated-orcid":false,"given":"Franziska","family":"Di\u00a0Pauli","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck  Innsbruck 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Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6909-6109","authenticated-orcid":false,"given":"Robert","family":"Barket","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2755-2043","authenticated-orcid":false,"given":"Klaus","family":"Berek","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Innsbruck  Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Egger","sequence":"additional","affiliation":[{"name":"Central Institute of Medical and Chemical Laboratory Diagnostics (ZIMCL) University Hospital of Innsbruck  Innsbruck 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