{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:56:04Z","timestamp":1791233764871,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["IIRG\u201009\u2010133014"],"award-info":[{"award-number":["IIRG\u201009\u2010133014"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Lifestyle factors have been implicated in the long\u2010lasting neurodegenerative process in prodromal Parkinson's disease (pPD). The aim was to investigate the associations between adherence to a Mediterranean diet (MeDi) and longitudinal changes of pPD probability and the development of Parkinson's disease (PD) or pPD in a Mediterranean older population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the Hellenic Longitudinal Investigation of Aging and Diet cohort (community\u2010dwelling individuals, aged\u2009\u2265\u200965\u2009years) were used. A detailed food frequency questionnaire was used to evaluate dietary intake and calculate MeDi adherence score, ranging from 0 to 55, with higher scores indicating higher adherence. The probability of pPD was calculated according to the updated Movement Disorder Society research criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 1047 non\u2010PD\/dementia with Lewy bodies (DLB) participants were followed for 3\u00a0\u00b1\u20091\u2009years. MeDi adherence was associated with lower increase in pPD probability over time (<jats:italic>b<\/jats:italic>\u00a0=\u2009\u22120.003, 95% confidence interval \u22120.006 to \u22120.001, <jats:italic>p<\/jats:italic>\u00a0=\u20090.010). Forty\u2010nine participants had incident possible\/probable pPD (i.e., pPD probability \u2265\u200930%). Compared to the participants in the lowest quartile of MeDi adherence, those in the higher quartiles had an approximately 60%\u201370% lower risk for possible\/probable pPD (<jats:italic>p<\/jats:italic> for trend\u00a00.003). MeDi\u2013pPD associations were driven by both motor and non\u2010motor pPD markers and not from risk markers. Also, 21 participants were diagnosed with PD\/DLB at follow\u2010up. For each unit increase in the MeDi score, there was a 9%\u201310% lower risk for PD\/DLB (hazard ratio 0.906 [95% confidence interval 0.823\u20130.997], <jats:italic>p<\/jats:italic>\u00a0=\u20090.044).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mediterranean diet adherence is associated with lower increase in pPD probability over time and lower possible\/probable pPD and PD\/DLB incidence in older Mediterranean people. More studies are needed to confirm our results in other populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15698","type":"journal-article","created":{"date-parts":[[2023,1,24]],"date-time":"2023-01-24T12:05:00Z","timestamp":1674561900000},"page":"934-942","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["<scp>Mediterranean<\/scp> diet is associated with a lower probability of prodromal Parkinson's disease and risk for Parkinson's disease\/dementia with Lewy bodies: A longitudinal study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8229-1400","authenticated-orcid":false,"given":"Maria I.","family":"Maraki","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Sciences Hellenic Mediterranean University  Crete Greece"},{"name":"Section of Sport Medicine and Biology of Exercise, School of Physical Education and Sport Science National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Yannakoulia","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics Harokopio University  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Xiromerisiou","sequence":"additional","affiliation":[{"name":"School of Medicine University of Thessaly  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Stefanis","sequence":"additional","affiliation":[{"name":"Center of Clinical, Experimental Surgery and Translational Research Biomedical Research Foundation of the Academy of Athens  Athens Greece"},{"name":"First Department of Neurology, Aiginition Hospital National and Kapodistrian University of Athens Medical School  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sokratis","family":"Charisis","sequence":"additional","affiliation":[{"name":"First Department of Neurology, Aiginition Hospital National and Kapodistrian University of Athens Medical School  Greece"},{"name":"Department of Neurology University of Texas Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Giagkou","sequence":"additional","affiliation":[{"name":"First Department of Neurology, Aiginition Hospital National and Kapodistrian University of Athens Medical School  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary H.","family":"Kosmidis","sequence":"additional","affiliation":[{"name":"Laboratory of Cognitive Neuroscience, School of Psychology Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efthimios","family":"Dardiotis","sequence":"additional","affiliation":[{"name":"School of Medicine University of Thessaly  Larissa Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgios M.","family":"Hadjigeorgiou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Medical School University of Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paraskevi","family":"Sakka","sequence":"additional","affiliation":[{"name":"Athens Association of Alzheimer's Disease and Related Disorders  Marousi Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6453-8908","authenticated-orcid":false,"given":"Nikolaos","family":"Scarmeas","sequence":"additional","affiliation":[{"name":"First Department of Neurology, Aiginition Hospital National and Kapodistrian University of Athens Medical School  Greece"},{"name":"Department of Neurology, Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Gertrude H. 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