{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T22:42:28Z","timestamp":1789512148147,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T00:00:00Z","timestamp":1675814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cardiovascular autonomic dysfunction may reportedly occur after a coronavirus\u2010disease\u20102019 (COVID\u201019) infection, but the available evidence is scattered. Here we sought to understand the acute and mid\u2010term effects of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection on cardiovascular autonomic function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a systematic PubMed, Embase, Web of Science, medRxiv, and bioRxiv search for cases of cardiovascular autonomic dysfunction during an acute SARS\u2010CoV\u20102 infection or post\u2010COVID\u201019 condition. The clinical\u2010demographic characteristics of individuals in the acute versus post\u2010COVID\u201019 phase were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We screened 6470 titles and abstracts. Fifty\u2010four full\u2010length articles were included in the data synthesis. One\u2010hundred and thirty\u2010four cases were identified: 81 during the acute SARS\u2010CoV\u20102 infection (24 thereof diagnosed by history) and 53 in the post\u2010COVID\u201019 phase. Post\u2010COVID\u201019 cases were younger than those with cardiovascular autonomic disturbances in the acute SARS\u2010CoV\u20102 phase (42 vs. 51\u2009years old, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002) and were more frequently women (68% vs. 49%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.034). Reflex syncope was the most common cardiovascular autonomic disorder in the acute phase (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008) and postural orthostatic tachycardia syndrome (POTS) the most frequent diagnosis in individuals with post\u2010COVID\u201019 orthostatic complaints (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Full recovery was more frequent in individuals with acute versus post\u2010COVID\u201019 onset of cardiovascular autonomic disturbances (43% vs. 15%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is evidence from the scientific literature about different types of cardiovascular autonomic dysfunction developing during and after COVID\u201019. More data about the prevalence of autonomic disorders associated with a SARS\u2010CoV\u20102 infection are needed to quantify its impact on human health.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15714","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T05:33:15Z","timestamp":1674624795000},"page":"1528-1539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Clinical presentation and management strategies of cardiovascular autonomic dysfunction following a <scp>COVID<\/scp>\u201019 infection \u2013 A systematic review"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8912-4736","authenticated-orcid":false,"given":"Diogo","family":"Reis\u00a0Carneiro","sequence":"first","affiliation":[{"name":"Department of Neurology Centro Hospitalar e Universit\u00e1rio de Coimbra  Coimbra Portugal"},{"name":"Faculty of Medicine University of Coimbra  Coimbra 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