{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:05:41Z","timestamp":1790795141194,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Amyotrophic lateral sclerosis (ALS) is among the most common motor neuron diseases in adults. Nevertheless, ALS remains fatal, despite decades of research and clinical trials, which has led to negative conclusions until recently in regard to four specific treatments. It is well known that we can learn from failures, and we consider that the time has come to present positive insight on this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We did a literature search using PubMed and Scopus for articles published in English from 1 January 2016, to 30 June 2022 dealing with \u201camyotrophic lateral sclerosis\u201d, diagnosis, treatment, and biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A comprehensive review of the literature on diagnosis, monitoring, and treatment of this condition showed convincing evidence that we are now able to diagnose earlier as well as to better monitor and treat ALS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although ALS is often difficult to diagnose and remains incurable, there are many indications that an optimistic view of ALS management in the coming years is now realistic.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15738","type":"journal-article","created":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T13:54:05Z","timestamp":1676123645000},"page":"1459-1464","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Time for optimism in <scp>amyotrophic lateral sclerosis<\/scp>"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1625-8845","authenticated-orcid":false,"given":"Philippe","family":"Corcia","sequence":"first","affiliation":[{"name":"CRMR SLA CHU Tours  Tours France"},{"name":"UMR1253 iBrain UMR Universit\u00e9 de Tours, INSERM  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lunetta","sequence":"additional","affiliation":[{"name":"ALS Unit, IRCCS Istituti Clinici Scientifici Maugeri  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Vourc'h","sequence":"additional","affiliation":[{"name":"UMR1253 iBrain UMR Universit\u00e9 de Tours, INSERM  Tours France"},{"name":"Laboratoire de Biochimie et Biologie Mol\u00e9culaire CHRU de Tours  Tours France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre\u2010Fran\u00e7ois","family":"Pradat","sequence":"additional","affiliation":[{"name":"CNRS, INSERM, Laboratoire d'Imagerie Biom\u00e9dicale Sorbonne Universit\u00e9  Paris France"},{"name":"D\u00e9partement de Neurologie, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re, Centre r\u00e9f\u00e9rent SLA APHP  Paris France"},{"name":"Northern Ireland Centre for Stratified Medicine Biomedical Sciences Research Institute, Ulster University, C\u2010TRIC, Altnagelvin Hospital  Derry\/Londonderry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Blasco","sequence":"additional","affiliation":[{"name":"UMR1253 iBrain UMR Universit\u00e9 de Tours, INSERM  Tours France"},{"name":"Northern Ireland Centre for Stratified Medicine Biomedical Sciences Research Institute, Ulster University, C\u2010TRIC, Altnagelvin Hospital  Derry\/Londonderry UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31287-4"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.184"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00414-2"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.235952"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2021.2024856"},{"key":"e_1_2_4_7_1","article-title":"Clinical and electrophysiological characteristics of respiratory onset amyotrophic lateral sclerosis: a single\u2010Centre study","author":"Chang MC","year":"2022","journal-title":"Acta Neurol Belg"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2016.1267768"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194316.91908.8a"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000730"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/362059a0"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00022-2"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3584"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2020.12.003"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-022-0095-x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2003715"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/17482960802521126"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26045"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-327129"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15321"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000569"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-021-10801-5"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25520"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1087"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70129-2"},{"key":"e_1_2_4_27_1","unstructured":"VALOR study and its open\u2010label extension evaluating the clinical efficacy and safety of Tofersen in adults with ALS and confirmed SOD1 mutation. American Neurological Association Annual Meeting; October 17\u201319 2021."},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-022-01237-4"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25276"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2021.04.008"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.11.004"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41397-019-0111-3"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-022-06906-5"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.211474"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-10181-2"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2589-7500(21)00274-0.Epub"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-021-00257-y"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317214"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.120079"},{"key":"e_1_2_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30089-9"},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03501.x"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-10971"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15738","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ene.15738","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15738","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:35:34Z","timestamp":1692693334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.15738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,23]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/ene.15738"],"URL":"https:\/\/doi.org\/10.1111\/ene.15738","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,23]]},"assertion":[{"value":"2022-12-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}