{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:32:21Z","timestamp":1785234741826,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013263","name":"Nasjonalforeningen for Folkehelsen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010100","name":"Sykehuset \u00d8stfold","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010100","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>There are currently no biomarkers to select cryptogenic stroke (CS) patients for monitoring with insertable cardiac monitors (ICMs), the most effective tool for diagnosing atrial fibrillation (AF) in CS. The purpose of this study was to assess clinically available biomarkers as predictors of AF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible CS and cryptogenic transient ischaemic attack patients underwent 12\u2010month monitoring with ICMs, clinical follow\u2010up and biomarker sampling. Levels of cardiac and thromboembolic biomarkers, taken within 14\u2009days from symptom onset, were compared between patients diagnosed with AF (<jats:italic>n<\/jats:italic>\u00a0=\u200974) during monitoring and those without AF (<jats:italic>n<\/jats:italic>\u00a0=\u2009185). Receiver operating characteristic curves were created. Biomarkers reaching area under the receiver operating characteristic curve\u00a0\u2265\u20090.7 were dichotomized by finding optimal cut\u2010off values and were used in logistic regression establishing their predictive value for increased risk of AF in unadjusted and adjusted models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>B\u2010type natriuretic peptide (BNP), N\u2010terminal pro\u2010brain natriuretic peptide (NT\u2010proBNP), creatine kinase, D\u2010dimer and high\u2010sensitivity cardiac troponin I and T were significantly higher in the AF than non\u2010AF group. BNP and NT\u2010proBNP reached the predefined area under the curve level, 0.755 and 0.725 respectively. Optimal cut\u2010off values were 33.5\u00a0ng\/l for BNP and 87\u2009ng\/l for NT\u2010proBNP. Regression analysis showed that NT\u2010proBNP was a predictor of AF in both unadjusted (odds ratio 7.72, 95% confidence interval 3.16\u201318.87) and age\u2010 and sex\u2010adjusted models (odds ratio 4.82, 95% confidence interval 1.79\u201312.96).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Several clinically established biomarkers were associated with AF. NT\u2010proBNP performed best as AF predictor and could be used for selecting patients for long\u2010term monitoring with ICMs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15746","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T10:59:41Z","timestamp":1676372381000},"page":"1352-1363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Biomarkers predictive of atrial fibrillation in patients with cryptogenic stroke. Insights from the Nordic Atrial Fibrillation and Stroke (<scp>NOR\u2010FIB<\/scp>) study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6213-4221","authenticated-orcid":false,"given":"Anna","family":"Tancin\u00a0Lambert","sequence":"first","affiliation":[{"name":"Department of Neurology \u00d8stfold Hospital Trust  Gr\u00e5lum Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Ratajczak\u2010Tretel","sequence":"additional","affiliation":[{"name":"Department of Neurology \u00d8stfold Hospital Trust  Gr\u00e5lum Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riadh","family":"Al\u2010Ani","sequence":"additional","affiliation":[{"name":"Department of Cardiology \u00d8stfold Hospital Trust  Gr\u00e5lum 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