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Our study aimed to explore alterations in dynamic functional connectivity (DFC), the gut microbiome and the bidirectional interaction in the BGM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Resting\u2010state functional magnetic resonance imaging (rs\u2010fMRI), fecal samples and clinical chacteristics were collected from 33 IBS patients and 32 healthy controls. We performed a systematic DFC analysis on rs\u2010fMRI. The gut microbiome was analyzed by 16S rRNA gene sequencing. Associations between DFC characteristics and microbial alterations were explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the DFC analysis, four dynamic functional states were identified. IBS patients exhibited increased mean dwell and fraction time in State 4, and reduced transitions from State 3 to State 1. Aberrant temporal properties in State 4 were only evident when choosing a short window (36\u2009s or 44\u2009s). Decreased functional connectivity (FC) variability was found in State 1 and State 3 in IBS patients, two of which (independent component [IC]51\u2010IC91, IC46\u2010IC11) showed significant correlations with clinical characteristics. Additionally, we identified nine significantly differential abundances in microbial composition. We also found that IBS\u2010related microbiota were associated with aberrant FC variability, although these exploratory results were obtained at an uncorrected threshold of significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although future studies are needed to confirm our results, the findings not only provide a new insight into the dysconnectivity hypothesis in IBS from a dynamic perspective, but also establish a possible link between DFC and the gut microbiome, which lays the foundation for future research on disrupted BGM interactions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15776","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T11:44:51Z","timestamp":1678535091000},"page":"3529-3539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of aberrant brain network dynamics with gut microbial composition uncovers disrupted brain\u2013gut\u2013microbiome interactions in irritable bowel syndrome: Preliminary findings"],"prefix":"10.1111","volume":"30","author":[{"given":"Lin","family":"Yang","sequence":"first","affiliation":[{"name":"Gansu Provincial Key Laboratory of Wearable Computing, School of Information Science and Engineering Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Lanzhou University Second Hospital  Lanzhou China"},{"name":"Gansu Province Clinical Research Center for Functional and Molecular Imaging  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Li","sequence":"additional","affiliation":[{"name":"Gansu Provincial Key Laboratory of Wearable Computing, School of Information Science and Engineering Lanzhou University  Lanzhou 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