{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:20:00Z","timestamp":1784805600849,"version":"3.55.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The genetics of late seizure or epilepsy secondary to traumatic brain injury (TBI) or stroke are poorly understood. We undertook a systematic review to test the association of single\u2010nucleotide polymorphisms (SNPs) with the risk of post\u2010traumatic epilepsy (PTE) and post\u2010stroke epilepsy (PSE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We followed methods from our prespecified protocol on PROSPERO to identify indexed articles for this systematic review. We collated the association statistics from the included articles to assess the association of SNPs with the risk of epilepsy amongst TBI or stroke patients. We assessed study quality using the Q\u2010Genie tool. We report odds ratios (OR) and hazard ratios with 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The literature search yielded 420 articles. We included 16 studies in our systematic review, of which seven were of poor quality. We examined published data on 127 SNPs from 32 genes identified in PTE and PSE patients. Eleven SNPs were associated with a significantly increased risk of PTE. Three SNPs, <jats:italic>TRMP6<\/jats:italic> rs2274924, <jats:italic>ALDH2<\/jats:italic> rs671, and <jats:italic>CD40<\/jats:italic> \u20101C\/T, were significantly associated with an increased risk of PSE, while two, <jats:italic>AT1R<\/jats:italic> rs12721273 and rs55707609, were significantly associated with reduced risk. The meta\u2010analysis for the association of the <jats:italic>APOE<\/jats:italic> \u025b4 with PTE was nonsignificant (OR 1.8, CI 0.6\u20135.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current evidence on the association of genetic polymorphisms in epilepsy secondary to TBI or stroke is of low quality and lacks validation. A collaborative effort to pool genetic data linked to epileptogenesis in stroke and TBI patients is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15777","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T14:39:31Z","timestamp":1678718371000},"page":"1791-1800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-2573","authenticated-orcid":false,"given":"Shubham","family":"Misra","sequence":"first","affiliation":[{"name":"Department of Neurology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1401-0181","authenticated-orcid":false,"given":"Terence J.","family":"Quinn","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido J.","family":"Falcone","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8976-5696","authenticated-orcid":false,"given":"Vijay K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine National University of Singapore and Division of Neurology, National University Health System  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"de Havenon","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yize","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Yale School of Public Health  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ece","family":"Eldem","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline A.","family":"French","sequence":"additional","affiliation":[{"name":"Department of Neurology NYU Grossman School of Medicine  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa Lin","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Neurology, School of Medical Sciences University of Campinas \u2013 UNICAMP  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse","family":"Dawson","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Liebeskind","sequence":"additional","affiliation":[{"name":"Department of Neurology University of California Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Kwan","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Medicine The University of Melbourne, Royal Melbourne Hospital  Melbourne Victoria Australia"},{"name":"Department of Neuroscience Monash University, Alfred Hospital  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9327-3707","authenticated-orcid":false,"given":"Nishant K.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Neurology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Epilepsy Data and Statistics | CDC [online].2020. 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