{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:47:58Z","timestamp":1790948878580,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The neurofilament light chain (NfL) assay is gradually becoming an essential diagnostic tool for the diagnosis of many neurological diseases including amyotrophic lateral sclerosis (ALS). Different methods for the determination of this biomarker in serum have been developed in recent years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We measured blood NfL in 429 patients referred to the tertiary ALS center of Montpellier, France using two different ultrasensitive methods (Ella\u2122 and Simoa\u2122) and we compared the clinical performances of these two approaches. We also converted NfL values into age and body mass index\u2010adjusted Z\u2010scores to assess cut\u2010off values of this biomarker in this clinical context.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We show comparable diagnostic and prognostic performance of Ella\u2122 and Simoa\u2122 technologies in ALS, with specificities and sensitivities exceeding 80% for both. We propose cut\u2010off values for serum NfL in this clinical context, thus enabling the routine clinical use of this biomarker.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The use of NfL in routine clinical practice will help predict survival and improve diagnostic accuracy by distinguishing ALS from other neurological diseases and motor neuron disease mimics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.15813","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T09:43:40Z","timestamp":1680947020000},"page":"1919-1927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Serum neurofilament light chain cut\u2010off definition for clinical diagnosis and prognosis of amyotrophic lateral sclerosis"],"prefix":"10.1111","volume":"30","author":[{"given":"Mehdi","family":"Brousse","sequence":"first","affiliation":[{"name":"LBPC\u2010PPC Universit\u00e9 Montpellier, CHU Montpellier, INM INSERM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8606-6814","authenticated-orcid":false,"given":"Constance","family":"Delaby","sequence":"additional","affiliation":[{"name":"LBPC\u2010PPC Universit\u00e9 Montpellier, CHU Montpellier, INM INSERM  Montpellier France"},{"name":"Hospital de la Santa Creu i Sant Pau \u2013 Biomedical Research Institute Sant Pau \u2013 Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"De\u00a0La\u00a0Cruz","sequence":"additional","affiliation":[{"name":"Explorations neurologiques et centre SLA Universit\u00e9 Montpellier, CHU Gui de Chauliac, INM, INSERM  Montpellier 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