{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:08:34Z","timestamp":1773893314575,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"Abstract<\/jats:title>Background and purpose<\/jats:title>Mutations in the gene encoding valosin\u2010containing protein (VCP<\/jats:italic>) are related to myriad medical conditions, including familial amyotrophic lateral sclerosis, inclusion body myopathy, and frontotemporal dementia. There are several reports of a link between these mutations and early onset Parkinson disease (PD).<\/jats:p><\/jats:sec>Case description<\/jats:title>We report a 53\u2010year\u2010old PD patient with VCP<\/jats:italic> mutation who later developed motor complications, thus receiving subthalamic nucleus deep brain stimulation (DBS) at the age of 56\u2009years. However, myopathy emerged 1.5\u2009years after surgery.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>With the phenotype variability of VCP<\/jats:italic>, DBS should be carefully evaluated, considering the possible unfavorable long\u2010term outcomes due to other symptoms of this mutation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15824","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T08:36:17Z","timestamp":1683880577000},"page":"2583-2586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Deep brain stimulation in Parkinson disease with valosin\u2010containing protein gene mutation"],"prefix":"10.1111","volume":"30","author":[{"given":"Yoon Seob","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology Ajou University School of Medicine Suwon\u2010si South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8658-3523","authenticated-orcid":false,"given":"Don Gueu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Ajou University School of Medicine Suwon\u2010si South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4397-6612","authenticated-orcid":false,"given":"Min Seung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Ajou University School of Medicine Suwon\u2010si South Korea"},{"name":"Department of Neurology Dongtan Sacred Heart Hospital Hallym University College of Medicine Hwaseong South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Han","family":"Yoon","sequence":"additional","affiliation":[{"name":"Department of Neurology Ajou University School of Medicine Suwon\u2010si South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,24]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M900992200"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.07.006"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-017-8467-2"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004240"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2012.03831.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2010.01428.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29005"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009649"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005530"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e328355aa94"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26080"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-022-00532-0"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2020.02.015"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2021.05.013"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26302"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:34:10Z","timestamp":1692682450000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.15824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,24]]},"references-count":15,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/ene.15824"],"URL":"https:\/\/doi.org\/10.1111\/ene.15824","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,24]]},"assertion":[{"value":"2022-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}