{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T01:24:40Z","timestamp":1789435480163,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Photophobia is a sensory disturbance provoked by light. Little is known about the association between photophobia and dementia with Lewy bodies (DLB). In this study, we aimed to identify the frequency and the neural basis of photophobia in prodromal and mild DLB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred and thirteen DLB patients, 53 Alzheimer's disease (AD) patients, 20\u2009AD and DLB patients, 31 patients with other neurocognitive diseases (including prodromal and mild demented patients), and 31 healthy elderly controls were included in this case\u2013control study. Photophobia was systematically looked for and compared between groups. Among a selection of 77 DLB patients, we used voxel\u2010based morphometry (VBM) to compare those with and those without photophobia (gray matter volume; SPM12, XjView, and Matlab R2021b software).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of photophobia was higher in the DLB group (47.3%) than in the other groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). The photophobia questionnaire score was higher in the DLB group than in the AD group (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Comparison between DLB patients with and those without photophobia showed decreased gray matter in the photophobia subgroup, in the right precentral cortex, in the eyelid motor region of Penfield's homunculus (<jats:italic>p<\/jats:italic>\u2009=\u20090.007, family\u2010wise error [FWE] corrected).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Photophobia is a quite frequent symptom of prodromal and mild DLB. The neural basis of photophobia in DLB involves the right precentral cortex, which could have a role in the decrease of cerebral excitability, but also the motricity of the eyelids.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15829","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T11:31:00Z","timestamp":1683545460000},"page":"2215-2221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neural correlates of photophobia in prodromal and mild dementia with Lewy bodies"],"prefix":"10.1111","volume":"30","author":[{"given":"Alice","family":"Tisserand","sequence":"first","affiliation":[{"name":"ICube Laboratory UMR 7357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), IMIS team and IRIS platform University of Strasbourg and CNRS  Strasbourg France"},{"name":"CM2R (Research and Resources Memory Center), Geriatric Day Hospital, Geriatrics Division University Hospitals of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9302-755X","authenticated-orcid":false,"given":"Benjamin","family":"Cretin","sequence":"additional","affiliation":[{"name":"ICube Laboratory UMR 7357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), IMIS team and IRIS platform University of Strasbourg and CNRS  Strasbourg France"},{"name":"CM2R, Neuropsychology Unit, Neurology Department, Head and Neck Division University Hospitals of Strasbourg  Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Mondino","sequence":"additional","affiliation":[{"name":"ICube Laboratory UMR 7357 and FMTS (F\u00e9d\u00e9ration de M\u00e9decine Translationnelle de Strasbourg), IMIS team and IRIS platform University of Strasbourg and CNRS  Strasbourg 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