{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:50:39Z","timestamp":1777359039398,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["318075"],"award-info":[{"award-number":["318075"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although the incidence of stroke in the young is rising, data on long\u2010term outcomes in these patients are scarce. We thus aimed to investigate the long\u2010term risk of recurrent vascular events and mortality in a multicenter study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We followed 396 consecutive patients aged 18\u201355\u2009years with ischemic stroke (IS) or transient ischemic attack (TIA) enrolled in three European centers during the period 2007\u20132010. A detailed outpatient clinical follow\u2010up assessment was performed between 2018 and 2020. When an in\u2010person follow\u2010up visit was not possible, outcome events were assessed using electronic records and registry data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During a median follow\u2010up of 11.8 (IQR 10.4\u201312.7) years, 89 (22.5%) patients experienced any recurrent vascular event, 62 (15.7%) had any cerebrovascular event, 34 (8.6%) had other vascular events, and 27 (6.8%) patients died. Cumulative 10\u2010year incidence rate per 1000 person\u2010years was 21.6 (95% CI 17.1\u201326.9) for any recurrent vascular event and 14.9 (95% CI 11.3\u201319.3) for any cerebrovascular event. The prevalence of cardiovascular risk factors increased over time, and 22 (13.5%) patients lacked any secondary preventive medication at the in\u2010person follow\u2010up. After adjustment for demographics and comorbidities, atrial fibrillation at baseline was found to be significantly associated with recurrent vascular events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This multicenter study shows a considerable risk of recurrent vascular events in young IS and TIA patients. Further studies should investigate whether detailed individual risk assessment, modern secondary preventive strategies, and better patient adherence may reduce recurrence risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15850","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T21:26:36Z","timestamp":1683753996000},"page":"2675-2683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Long\u2010term risk of recurrent vascular events and mortality in young stroke patients: Insights from a multicenter study"],"prefix":"10.1111","volume":"30","author":[{"given":"Jenna","family":"Broman","sequence":"first","affiliation":[{"name":"Department of Neurology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9043-0378","authenticated-orcid":false,"given":"Simon","family":"Fandler\u2010H\u00f6fler","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"von Sarnowski","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medicine Greifswald  Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Elmegiri","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-6576","authenticated-orcid":false,"given":"Thomas","family":"Gattringer","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz  Graz Austria"},{"name":"Division of Neuroradiology, Vascular and Interventional Radiology, Department of Radiology Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Holbe","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medicine Greifswald  Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"von der Linden","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Malinowski","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medicine Greifswald  Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juha","family":"Martola","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Helsinki and Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3138-5225","authenticated-orcid":false,"given":"Daniela","family":"Pinter","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Ropele","sequence":"additional","affiliation":[{"name":"Department of Neurology Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Schminke","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medicine Greifswald  Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Turgut","family":"Tatlisumak","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience, Institute of Neurosciences and Physiology, Sahlgrenska Academy at University of Gothenburg &amp; 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