{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:34:55Z","timestamp":1790771695305,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T00:00:00Z","timestamp":1686182400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The prognosis of prolonged (28\u2009days to 3\u2009months post\u2010onset) disorders of consciousness (pDoC) due to anoxic brain injury is uncertain. The present study aimed to evaluate the long\u2010term outcome of post\u2010anoxic pDoC and identify the possible predictive value of demographic and clinical information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This is a systematic review and meta\u2010analysis. The rates of mortality, any improvement in clinical diagnosis, and recovery of full consciousness at least 6\u2009months after severe anoxic brain injury were evaluated. A cross\u2010sectional approach searched for differences in baseline demographic and clinical characteristics between survivors and non\u2010survivors, patients improved versus not improved, and patients who recovered full consciousness versus not recovered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven studies were identified. The pooled rates of mortality, any clinical improvement and recovery of full consciousness were 26%, 26% and 17%, respectively. Younger age, baseline diagnosis of minimally conscious state versus vegetative state\/unresponsive wakefulness syndrome, higher Coma Recovery Scale Revised total score, and earlier admission to intensive rehabilitation units were associated with a significantly higher likelihood of survival and clinical improvement. These same variables, except time of admission to rehabilitation, were also associated with recovery of full consciousness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with anoxic pDoC might improve over time up to full recovery of consciousness and some clinical characteristics can help predict clinical improvement. These new insights could support clinicians and caregivers in the decision\u2010making on patient management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15899","type":"journal-article","created":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T07:41:29Z","timestamp":1685346089000},"page":"3913-3927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Long\u2010term clinical evolution of patients with prolonged disorders of consciousness due to severe anoxic brain injury: A meta\u2010analytic study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3834-6392","authenticated-orcid":false,"given":"Alfonso","family":"Magliacano","sequence":"first","affiliation":[{"name":"IRCCS Fondazione Don Carlo Gnocchi ONLUS  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"De\u00a0Bellis","sequence":"additional","affiliation":[{"name":"Polo 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