{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T10:41:58Z","timestamp":1788172918252,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Previous studies demonstrated cognitive deficits in patients with peripheral vestibulopathy (PVP) with dysfunction of spatial navigation and orientation, but also documented cognitive decline in nonspatial abilities. This study evaluates cognitive deficits in patients with unilateral vestibulopathy (UVP) as well as bilateral vestibulopathy (BVP) in multiple cognitive domains using common screening tests to reliably detect these deficits in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective study compared patients with UVP and BVP to age\u2010 and sex\u2010matched healthy controls (HC). Tests included the Alzheimer's Disease Assessment Scale (ADAS), Mini\u2010Mental Status Examination (MMSE), Trail Making Test Part A and B, Clock Drawing Task, Executive Interview\u201025 (EXIT25), Dementia Detection (DemTect), and the Judgment of Line Orientation (JLO). The Montgomery\u2010\u00c5sberg Depression Rating Scale was used to control for depression. Videonystagmography objectively reconfirmed PVP. The Vertigo Symptoms Scale and the Dizziness Handicap Inventory were used to assess for symptom severity and restrictions of activities of daily living.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty\u2010one patients (65 UVP, 16 BVP) were compared to 55 HC. Patients showed impairment in ADAS, MMSE, DemTect, EXIT25, and JLO. No differences between UVP and BVP were detected. The relative risk (RR) estimates of developing cognitive deficits following PVP were increased. The RR for the ADAS was higher in BVP (RR\u2009=\u20094.91, 95% confidence interval [CI] =\u20091.87\u201312.9,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) than in UVP (RR\u2009=\u20093.75, 95% CI\u2009=\u20091.65\u20138.51,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), but was similar for the MMSE and DemTect between groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with PVP showed deficits in multiple cognitive domains including nonspatial cognitive abilities. Vestibulopathy could be a risk factor for the development of cognitive impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.15907","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T01:22:12Z","timestamp":1686014532000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cognitive deficits in patients with peripheral vestibular dysfunction"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5533-2657","authenticated-orcid":false,"given":"Mark","family":"Obermann","sequence":"first","affiliation":[{"name":"Department of Neurology, Dizziness and Vertigo Center Essen University Hospital Essen  Essen Germany"},{"name":"Department of Neurology Weser\u2010Egge Hospital H\u00f6xter  H\u00f6xter 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