{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:37:07Z","timestamp":1790674627450,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["606650"],"award-info":[{"award-number":["606650"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>While individuals with Huntington disease (HD) show memory impairment that indicates hippocampal dysfunction, the available literature does not consistently identify structural evidence for involvement of the whole hippocampus but rather suggests that hippocampal atrophy may be confined to certain hippocampal subregions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We processed T1\u2010weighted MRI from IMAGE\u2010HD study using FreeSurfer 7.0 and compared the volumes of the hippocampal subfields among 36 early motor symptomatic (symp\u2010HD), 40 pre\u2010symptomatic (pre\u2010HD), and 36 healthy control individuals across three timepoints over 36\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mixed\u2010model analyses revealed significantly lower subfield volumes in symp\u2010HD, compared with pre\u2010HD and control groups, in the subicular regions of the perforant\u2010pathway: presubiculum, subiculum, dentate gyrus, tail, and right molecular layer. These adjoining subfields aggregated into a single principal component, which demonstrated an accelerated rate of atrophy in the symp\u2010HD. Volumes between pre\u2010HD and controls did not show any significant difference. In the combined HD groups, CAG repeat length and disease burden score were associated with presubiculum, molecular layer, tail, and perforant\u2010pathway subfield volumes. Hippocampal left tail and perforant\u2010pathway subfields were associated with motor onset in the pre\u2010HD group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hippocampal subfields atrophy in early symptomatic HD affects key regions of the perforant\u2010pathway, which may implicate the distinctive memory impairment at this stage of illness. Their volumetric associations with genetic and clinical markers suggest the selective susceptibility of these subfields to mutant Huntingtin and disease progression.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15918","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T11:54:45Z","timestamp":1686570885000},"page":"2650-2660","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Selective perforant\u2010pathway atrophy in Huntington disease: <scp>MRI<\/scp> analysis of hippocampal subfields"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7120-6984","authenticated-orcid":false,"given":"Pierre","family":"Wibawa","sequence":"first","affiliation":[{"name":"Neuropsychiatry Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Melbourne Neuropsychiatry Center University of Melbourne  Parkville Victoria Australia"},{"name":"School of Psychological Sciences and Turner Institute for Brain and Mental Health Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Walterfang","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Melbourne Neuropsychiatry Center University of Melbourne  Parkville Victoria Australia"},{"name":"Florey Institute of Neuroscience and Mental Health University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0534-3718","authenticated-orcid":false,"given":"Charles B.","family":"Malpas","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Melbourne Neuropsychiatry Center University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifat","family":"Glikmann\u2010Johnston","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences and Turner Institute for Brain and Mental Health Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govinda","family":"Poudel","sequence":"additional","affiliation":[{"name":"Mary Mackillop Institute for Health Research Australian Catholic University  Fitzroy Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeel","family":"Razi","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences and Turner Institute for Brain and Mental Health Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Hannan","sequence":"additional","affiliation":[{"name":"Florey Institute of Neuroscience and Mental Health University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Velakoulis","sequence":"additional","affiliation":[{"name":"Neuropsychiatry Royal Melbourne Hospital  Parkville Victoria Australia"},{"name":"Melbourne Neuropsychiatry Center University of Melbourne  Parkville Victoria Australia"},{"name":"Florey Institute of Neuroscience and Mental Health University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0718-6760","authenticated-orcid":false,"given":"Nellie","family":"Georgiou\u2010Karistianis","sequence":"additional","affiliation":[{"name":"School of Psychological Sciences and Turner Institute for Brain and Mental Health Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1039856218791036"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn025"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474-4422(09)70170-x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.01.015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2017.04.022"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2019.07.014"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2019.04.006"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2015-312413"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.05.015"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1992.tb00824.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.5.487"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhw010"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(79)90005-4"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1063(1999)9:3<206::AID-HIPO2>3.0.CO;2-H"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/9.3.197"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2602"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3873-12.2013"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.10.001"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2004.00241.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.02.084"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.04.042"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25326"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.05.001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2015.01389"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-018-1617-1"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.23324"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2017.00084"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/2398212817701448"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1149381"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.07.015"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(94)90001-9"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.19-07-02522.1999"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25624"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24162"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0306-4522(97)00068-7"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2014.11.010"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-019-02022-4"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.689332"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg075"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp467"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa066"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00862983"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03169.x"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23416"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.03.005"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06899-3"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww021"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.104"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.2368"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1818042116"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.15918","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T01:16:09Z","timestamp":1692321369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.15918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,23]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/ene.15918"],"URL":"https:\/\/doi.org\/10.1111\/ene.15918","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,23]]},"assertion":[{"value":"2022-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}