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Patients underwent semistandardized interviewing about symptoms with reported onset after SARS\u2010CoV\u20102 infection, neurological examination, and comprehensive diagnostic workup.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reported new onset symptoms after infection included fatigue (77.6%), subjective cognitive impairment (72.4%), headache (47.7%), loss of smell and\/or taste (43.2%), and sleep disturbances (42.2%). Most patients had a mild coronavirus disease (COVID\u201019) disease course (84%) and reported comorbidities (71%), of which the most frequent were psychiatric disorders (34%). Frequency of symptoms was not associated with age, sex, or severity of COVID\u201019 course. A comprehensive diagnostic workup revealed no neurological abnormalities in the clinical examination, or electrophysiological or imaging assessments in the majority of patients (<jats:italic>n<\/jats:italic>\u2009=\u2009143, 91.7%). Neuropsychological assessment of a subgroup of patients (<jats:italic>n<\/jats:italic>\u2009=\u200928, 17.9%) showed that cognitive impairments in executive functions and attention, anxiety, depression, and somatization symptoms were highly common.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this systematic registry, we identified fatigue, cognitive impairment, and headache as the most frequently reported persisting complaints after SARS\u2010CoV\u20102 infection. Structural neurological findings were rare. We also suspect a link between the growing burden of the COVID\u201019 pandemic on personal lives and the increase in reported neurological and psychiatric complaints.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15923","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T13:39:21Z","timestamp":1686577161000},"page":"2713-2725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Reported neurological symptoms after severe acute respiratory syndrome coronavirus type 2 infection: A systematic diagnostic approach"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5119-8665","authenticated-orcid":false,"given":"Birgit","family":"Ludwig","sequence":"first","affiliation":[{"name":"Department of Neurology Medical University of Vienna  Vienna Austria"},{"name":"Comprehensive Center for Clinical Neurosciences &amp; Mental Health Medical University of Vienna  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