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We examined whether the alpha band power measured with magnetoencephalography (MEG) is associated with the different cognitive domains affected by MS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010eight MS patients and 47 healthy controls underwent MEG, T1\u2010 and FLAIR\u2010weighted magnetic resonance imaging (MRI), and neuropsychological testing. Alpha power in the occipital cortex was quantified in the alpha1 (8\u201310\u2009Hz) and alpha2 (10\u201312\u2009Hz) bands. Next, we performed best subset regression to assess the added value of neurophysiological measures to commonly available MRI measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alpha2 power significantly correlated with information processing speed (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and was always retained in all multilinear models, whereas thalamic volume was retained in 80% of all models. Alpha1 power was correlated with visual memory (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) but only retained in 38% of all models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Alpha2 (10\u201312\u2009Hz) power in rest is associated with IPS, independent of standard MRI parameters. This study stresses that a multimodal assessment, including structural and functional biomarkers, is likely required to characterize cognitive impairment in MS. Resting\u2010state neurophysiology is thus a promising tool to understand and follow up changes in IPS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15927","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T09:53:42Z","timestamp":1686909222000},"page":"2793-2800","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Reduced alpha2 power is associated with slowed information processing speed in multiple sclerosis"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8641-054X","authenticated-orcid":false,"given":"Alexander","family":"De\u00a0Cock","sequence":"first","affiliation":[{"name":"Nationaal Multiple Sclerose Centrum  Melsbroek Belgium"},{"name":"Center for Neurosciences (C4N) Vrije Universiteit Brussel (VUB)  Brussels Belgium"},{"name":"AIMS Lab, Center for Neurosciences, UZ Brussel Vrije Universiteit Brussel  Brussels 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