{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T03:54:36Z","timestamp":1787630076941,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>This study was undertaken to determine the association of hospital\u2010diagnosed morbidity and recent surgery with risk of subsequent Guillain\u2013Barr\u00e9 syndrome (GBS) development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a nationwide population\u2010based case\u2013control study of all patients with first\u2010time hospital\u2010diagnosed GBS in Denmark between 2004 and 2016 and 10 age\u2010, sex\u2010, and index date\u2010matched population controls per case. Hospital\u2010diagnosed morbidities included in the Charlson Comorbidity Index were assessed as GBS risk factors up to 10\u2009years prior to the GBS index date. Incident major surgery was assessed within 5\u2009months prior.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the 13\u2010year study period, there were 1086 incident GBS cases, whom we compared with 10,747 matched controls. Any pre\u2010existing hospital\u2010diagnosed morbidity was observed in 27.5% of GBS cases and 20.0% of matched controls, yielding an overall matched odds ratio (OR) of 1.6 (95% confidence interval [CI] =\u20091.4\u20131.9). The strongest associations were found for leukemia, lymphoma, diabetes, liver disease, myocardial infarction, congestive heart failure, and cerebrovascular disease, with 1.6\u2010 to 4.6\u2010fold increased risks of subsequent GBS. GBS risk was strongest for morbidities newly diagnosed during the past 5\u2009months (OR\u2009=\u20094.1, 95% CI\u2009=\u20093.0\u20135.6). Surgical procedures within 5\u2009months prior were observed in 10.6% of cases and 5.1% of controls, resulting in a GBS OR of 2.2 (95% CI\u2009=\u20091.8\u20132.7). Risk of developing GBS was highest during the first month following surgery (OR\u2009=\u20093.7, 95% CI\u2009=\u20092.6\u20135.2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this large nationwide study, individuals with hospital\u2010diagnosed morbidity and recent surgery had a considerably increased risk of GBS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15955","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T15:59:38Z","timestamp":1687881578000},"page":"3277-3285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Hospital\u2010diagnosed morbidities and recent surgery as risk factors for developing <scp>Guillain\u2013Barr\u00e9<\/scp> syndrome"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2210-6020","authenticated-orcid":false,"given":"Lotte S.","family":"Levison","sequence":"first","affiliation":[{"name":"Department of Neurology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reimar W.","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Neurology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00339-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.121"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.66.6.706"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.08.005"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.3.635"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.5.605"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2004.00272.x"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/121.4.767"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000310983.38724.d4"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.08.014"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00562-6"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0250-9"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.172"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000006246"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2016.02.003"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.8.2346"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2016.1193006"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-011-8294-7"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5728(99)00195-2"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2010.07.011"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-018-0016-9"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S37587"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9930-3"},{"key":"e_1_2_11_25_1","unstructured":"International Classification of Diseases (ICD).World Health Organization.https:\/\/www.who.int\/classifications\/icd\/en\/. 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