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In this randomized controlled double\u2010blind study, the effects of tDCS whilst patients were in rehabilitation were tested at the group level and according to their diagnosis and aetiology to better target DoC patients who might repond to tDCS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients received 2\u2009mA tDCS or sham applied over the left prefrontal cortex for 4\u2009weeks. Behavioural assessments were performed weekly and up to 3 months\u2019 follow\u2010up. Analyses were conducted at the group and subgroup levels based on the diagnosis (minimally conscious state [MCS] and unresponsive wakefulness syndrome) and the aetiology (traumatic or non\u2010traumatic). Interim analyses were planned to continue or stop the trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The trial was stopped for futility when 62 patients from 10 centres were enrolled (44\u2009\u00b1\u200914\u2009years, 37\u2009\u00b1\u200924.5\u2009weeks post\u2010injury, 18 women, 32 MCS, 39 non\u2010traumatic). Whilst, at the group level, no treatment effect was found, the subgroup analyses at 3 months\u2019 follow\u2010up revealed a significant improvement for patients in MCS and with traumatic aetiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transcranial direct current stimulation during rehabilitation does not seem to enhance patients' recovery. However, diagnosis and aetiology appear to be important factors leading to a response to the treatment. These findings bring novel insights into possible cortical plasticity changes in DoC patients given these differential results according to the subgroups of patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15974","type":"journal-article","created":{"date-parts":[[2023,7,9]],"date-time":"2023-07-09T20:53:06Z","timestamp":1688935986000},"page":"3016-3031","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Sham\u2010controlled randomized multicentre trial of transcranial direct current stimulation for prolonged disorders of consciousness"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5991-1747","authenticated-orcid":false,"given":"Aurore","family":"Thibaut","sequence":"first","affiliation":[{"name":"Coma Science Group, GIGA\u2010Consciousness, Centre du Cerveau<sup>2<\/sup> University and University Hospital of Li\u00e8ge  Li\u00e8ge 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