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Although it has mainly been associated with natalizumab treatment, its appearance with other immunosuppressive therapies has also been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this case report is to describe the development of progressive multifocal encephalopathy in a patient with relapsing\u2013remitting multiple sclerosis treated with ocrelizumab without previous use of natalizumab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A summary of the presentation and disease course is provided, presented in the context of the current literature and likely pathophysiology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.15988","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T09:46:27Z","timestamp":1690191987000},"page":"3357-3361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Progressive multifocal 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Quiroga","family":"Varela","sequence":"additional","affiliation":[{"name":"Neurodegeneration and Neuroinflammation Research Group Girona Biomedical Research Institute (IDIBGI)  Salt Spain"},{"name":"Instituto de Salud Carlos III, Redes de Investigaci\u00f3n Cooperativa Orientada a Resultados en Salud (RICORS), Red de Enfermedades inflamatorias (RD21\/0002\/0063)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Robles\u2010Cede\u00f1o","sequence":"additional","affiliation":[{"name":"Girona Neuroimmunology and Multiple Sclerosis Unit, Neurology Department Dr. Josep Trueta University Hospital and Santa Caterina Hospital  Salt Spain"},{"name":"Instituto de Salud Carlos III, Redes de Investigaci\u00f3n Cooperativa Orientada a Resultados en Salud (RICORS), Red de Enfermedades inflamatorias (RD21\/0002\/0063)  Madrid Spain"},{"name":"Medical Sciences Department University of Girona  Girona 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