{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:15:14Z","timestamp":1789398914226,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>The best management of acute ischemic stroke patients with a minor stroke and large vessel occlusion is still uncertain. Specific clinical and radiological data may help to select patients who would benefit from endovascular therapy (EVT). We aimed to evaluate the relevance of National Institutes of Health Stroke Scale (NIHSS) subitems for predicting the potential benefit of providing EVT after intravenous thrombolysis (IVT; \u201cbridging treatment\u201d) versus IVT alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We extracted demographic, clinical, risk factor, radiological, revascularization and outcome data of consecutive patients with M1 or proximal M2 middle cerebral artery occlusion and admission NIHSS scores of 0\u20135 points, treated with IVT\u2009\u00b1\u2009EVT between May 2005 and March 2021, from nine prospectively constructed stroke registries at seven French and two Swiss comprehensive stroke centers. Adjusted interaction analyses were performed between admission NIHSS subitems and revascularization modality for two primary outcomes at 3\u2009months: non\u2010excellent functional outcome (modified Rankin Scale score 2\u20136) and difference in NIHSS score between 3\u2009months and admission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 533 patients included (median age 68.2\u2009years, 46% women, median admission NIHSS score 3), 136 (25.5%) initially received bridging therapy and 397 (74.5%) received IVT alone. Adjusted interaction analysis revealed that only facial palsy on admission was more frequently associated with excellent outcome in patients treated by IVT alone versus bridging therapy (odds ratio\u20090.47, 95% confidence interval\u20090.24\u20130.91;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.013). Regarding NIHSS difference at 3\u2009months, no single NIHSS subitem interacted with type of revascularization.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This retrospective multicenter analysis found that NIHSS subitems at admission had little value in predicting patients who might benefit from bridging therapy as opposed to IVT alone. Further research is needed to identify better markers for selecting EVT responders with minor strokes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16009","type":"journal-article","created":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T08:53:45Z","timestamp":1690707225000},"page":"3741-3750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relevance of National Institutes of Health Stroke Scale subitems for best revascularization therapy in minor stroke patients with large vessel occlusion: An observational multicentric study"],"prefix":"10.1111","volume":"30","author":[{"given":"Paola","family":"Palazzo","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences, Neurology Service, Stroke Centre Lausanne University Hospital  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Padlina","sequence":"additional","affiliation":[{"name":"Stroke Research Center Bern, Department of Neurology, Inselspital University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Dobrocky","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology, Inselspital University Hospital and University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4429-2714","authenticated-orcid":false,"given":"Davide","family":"Strambo","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences, Neurology Service, Stroke Centre Lausanne University Hospital  Lausanne 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