{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T12:10:44Z","timestamp":1774699844088,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,13]],"date-time":"2023-08-13T00:00:00Z","timestamp":1691884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Existing data regarding the link between COVID\u201019 vaccine and myasthenia gravis (MG) are scarce. We aimed to assess the association between Pfizer\u2010BioNTech vaccine with both new\u2010onset MG and MG exacerbation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For the first aim, we conducted a nested case\u2013control study in a cohort of 3,052,467 adults, without a diagnosis of MG, from the largest healthcare provider in Israel. Subjects were followed from January 1, 2021 until June 30, 2022 for the occurrence of MG. Ten randomly selected controls were matched to each case of new\u2010onset MG on age and sex. For the second aim, a nested case\u2013control study was conducted in a cohort of 1446 MG patients. Four randomly selected MG patients (controls) were matched to each case of MG exacerbation. Exposure to COVID\u201019 vaccine in the prior 4\u2009weeks was assessed in cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 332 patients had new\u2010onset MG and were matched with 3320 controls. Multivariable conditional logistic regression models showed that the odds ratio (OR) for new\u2010onset MG, associated with COVID\u201019 vaccine, was 1.14 (95% CI 0.73\u20131.78). The results were consistent in sensitivity analysis that used more stringent criteria to define MG. Overall, 62 patients with MG exacerbation were matched to 248 MG controls. The multivariable OR for MG exacerbation, associated with COVID\u201019 vaccine, was 1.35 (95% CI 0.37\u20134.89). All results were similar when the prior exposure to COVID\u201019 vaccine was extended to 8\u2009weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that Pfizer\u2010BioNTech vaccine is not associated with increased risk of new\u2010onset nor exacerbation of MG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16025","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T18:38:44Z","timestamp":1691519924000},"page":"3868-3876","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between <scp>COVID<\/scp>\u201019 vaccination and myasthenia gravis: A population\u2010based, nested case\u2013control study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6735-4327","authenticated-orcid":false,"given":"Anat","family":"Arbel","sequence":"first","affiliation":[{"name":"Department of Internal Medicine B 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