{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:14:07Z","timestamp":1793060047105,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T00:00:00Z","timestamp":1692921600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008038","name":"Neuromuscular Research Association Basel","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute hepatitis E virus (HEV) infection has recently emerged as a potential trigger for acute dysimmune neuropathies, but prospective controlled studies are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the frequency of concomitant acute HEV infection in patients with neuralgic amyotrophy (NA), Guillain\u2013Barr\u00e9 syndrome (GBS), and Bell's palsy with a matched control population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Swiss multicenter, prospective, observational, matched case\u2013control study over 3\u2009years (September 2019\u2013October 2022). Neurological cases with NA, GBS, or Bell's palsy were recruited within 1\u2009month of disease onset. Healthy controls were matched for age, sex, geographical location, and timing of blood collection. Diagnostic criteria for acute hepatitis E were reactive serum anti\u2010HEV IgM and IgG assays (ELISA test) and\/or HEV RNA detection in serum by real\u2010time polymerase chain reaction (RT\u2010PCR). RT\u2010PCR was performed on sera to confirm IgM positivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 180 patients (59 GBS, 51 NA, 70 Bell's palsy cases) and corresponding matched controls (blood donors) with median age 51\u2009years for both groups and equal gender distribution. Six IgM+ cases were detected in the NA, two in the GBS, and none in the Bell's palsy group. Two controls were anti\u2010HEV IgM\u2010positive. At disease onset, most cases with acute HEV infection had increased liver enzymes. A moderate association (<jats:italic>p<\/jats:italic>\u2009=\u20090.027, Fisher's exact test; Cram\u00e9r's <jats:italic>V<\/jats:italic>\u2009=\u2009\u22120.25) was observed only between acute HEV infection and NA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This prospective observational study suggests an association between concomitant acute HEV infection and NA, but not with GBS or Bell's palsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16030","type":"journal-article","created":{"date-parts":[[2023,8,7]],"date-time":"2023-08-07T14:03:00Z","timestamp":1691416980000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Neuropathies related to hepatitis E virus infection: A prospective, matched case\u2013control study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8662-9656","authenticated-orcid":false,"given":"Paolo","family":"Ripellino","sequence":"first","affiliation":[{"name":"Department of Neurology Neurocenter of Southern Switzerland EOC  Lugano Switzerland"},{"name":"Faculty of Biomedical Sciences Universit\u00e0 della Svizzera Italiana  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7572-8811","authenticated-orcid":false,"given":"Agustina Maria","family":"Lascano","sequence":"additional","affiliation":[{"name":"Neurology Division, Department of Clinical Neuroscience University Hospitals of Geneva and Faculty of Medicine, University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Scheidegger","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital Bern University Hospital and University 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