{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:45:10Z","timestamp":1780987510843,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:00:00Z","timestamp":1692835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The weight of outcome predictors in acute ischemic stroke (AIS) patients older than 60\u2009years is not necessarily mirrored in the younger population, posing the question of whether outcome determinants specific for the latter might vary. Very few data are available on predictors of outcome in young AIS patients receiving endovascular treatment (EVT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed data for patients aged between 16 and 55\u2009years from the Italian Registry of Endovascular Treatment in Acute Stroke. We divided our population into patients &lt;45\u2009years old and patients aged between 45 and 55\u2009years. After testing the differences between groups in terms of 90\u2010day modified Rankin Scale (mRS) 0\u20132, mortality, and symptomatic intracranial hemorrhage, we looked for predictors of poor outcome (mRS 3\u20136), death, and symptomatic intracerebral hemorrhage in the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 438 patients younger than 45\u2009years and 817 aged 45\u201355\u2009years were included; 284 (34.8%) patients aged 45\u201355\u2009years and 112 (25.6%) patients younger than 45\u2009years old showed poor 90\u2010day functional outcome (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Predictors of poor outcome in the older group were baseline National Institutes of Health Stroke Scale (NIHSS; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), diabetes (<jats:italic>p<\/jats:italic>\u2009=\u20090.027), poor collateral status (<jats:italic>p<\/jats:italic>\u2009=\u20090.036), and groin puncture\u2010to\u2010recanalization time (<jats:italic>p<\/jats:italic>\u2009=\u20090.010), whereas Thrombolysis in Cerebral Infarction (TICI) 2b\u20133 had an inverse association (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Predictors of poor outcome in patients younger than 45\u2009years were baseline NIHSS (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and groin puncture\u2010to\u2010recanalization time (<jats:italic>p<\/jats:italic>\u2009=\u20090.015), whereas an inverse association was found for baseline Alberta Stroke Program Early CT Score (<jats:italic>p<\/jats:italic>\u2009=\u20090.010) and TICI 2b\u20133 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Approximately one third of young adults treated with EVT do not reach a good functional outcome. Fast and successful recanalization, rather than common risk factors, has a major role in determining clinical outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16035","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T08:55:15Z","timestamp":1691744115000},"page":"3751-3760","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mechanical thrombectomy in young patients with large vessel occlusion\u2010related ischemic stroke: Data from the Italian Registry of Endovascular Treatment in Acute Stroke"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8481-6327","authenticated-orcid":false,"given":"Ettore","family":"Nicolini","sequence":"first","affiliation":[{"name":"Department of Human Neurosciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Saia","sequence":"additional","affiliation":[{"name":"Hospital Santa Corona Pietra Ligure  Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Lorenzano","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Pracucci","sequence":"additional","affiliation":[{"name":"University of Florence  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3911-3278","authenticated-orcid":false,"given":"Marta","family":"Iacobucci","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"De\u00a0Michele","sequence":"additional","affiliation":[{"name":"Department of Human Neurosciences Sapienza University of Rome  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Vallone","sequence":"additional","affiliation":[{"name":"University Hospital Modena  Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Bergui","sequence":"additional","affiliation":[{"name":"University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7569-1414","authenticated-orcid":false,"given":"Marina","family":"Diomedi","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Nencini","sequence":"additional","affiliation":[{"name":"Careggi University Hospital  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5906-8718","authenticated-orcid":false,"given":"Rossana","family":"Tassi","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero Universitaria Senese  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Saletti","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliero Universitaria di Ferrara  Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Puglielli","sequence":"additional","affiliation":[{"name":"Azienda Sanitria Locale 4 Teramo  Teramo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Naldi","sequence":"additional","affiliation":[{"name":"Ospedale San Giovanni Bosco  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Lucio","family":"Vinci","sequence":"additional","affiliation":[{"name":"University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Giannini","sequence":"additional","affiliation":[{"name":"University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Malfatto","sequence":"additional","affiliation":[{"name":"Istituti di Ricovero e Cura a Carattere Scientifico \u2010 IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menozzi","family":"Roberto","sequence":"additional","affiliation":[{"name":"Ospedale Maggiore di Parma  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele G.","family":"Romano","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Universitaria S. 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