{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:31:29Z","timestamp":1790735489031,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:00:00Z","timestamp":1694304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exergaming has been proposed to improve gait and balance disorders in Parkinson's disease (PD) patients. We aimed to assess the efficacy of a home\u2010based, tailored, exergaming training system designed for PD patients with dopa\u2010resistant gait and\/or balance disorders in a controlled randomized trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We recruited PD patients with dopa\u2010resistant gait and\/or balance disorders. Patients were randomly assigned (1:1 ratio) to receive 18 training sessions at home by playing a tailored exergame with full\u2010body movements using a motion capture system (Active group), or by playing the same game with the computer's keyboard (Control group). The primary endpoint was the between\u2010group difference in the Stand\u2010Walk\u2010Sit Test (SWST) duration change after training. Secondary outcomes included parkinsonian clinical scales, gait recordings, and safety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty PD patients were enrolled and randomized. After training, no significant difference in SWST change was found between groups (mean change SWST duration [SD] \u22123.71 [18.06] s after Active versus \u22120.71 [3.41] s after Control training,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.61). Some 32% of patients in the Active and 8% in the Control group were considered responders to the training program (e.g., SWST duration change \u22652\u2009s,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03). The clinical severity of gait and balance disorders also significantly decreased after Active training, with a between\u2010group difference in favor of the Active training (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0082). Home\u2010based training induced no serious adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Home\u2010based training using a tailored exergame can be performed safely by PD patients and could improve gait and balance disorders. Future research is needed to investigate the potential of exergaming.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16055","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T01:59:35Z","timestamp":1694397575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Home\u2010based exergaming to treat gait and balance disorders in patients with Parkinson's disease: A phase II randomized controlled trial"],"prefix":"10.1111","volume":"31","author":[{"given":"Dijana","family":"Nuic","sequence":"first","affiliation":[{"name":"Paris Brain Institute CNRS UMR 7225 INSERM 1127 Sorbonne University  Paris France"},{"name":"LabCom Brain e\u2010Novation Paris Brain Institute  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sjors","family":"van\u00a0de\u00a0Weijer","sequence":"additional","affiliation":[{"name":"Donders Institute for Brain, Cognition, and Behavior and Department of Neurology Center of Expertise for Parkinson and Movement Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Department of Neurology Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saoussen","family":"Cherif","sequence":"additional","affiliation":[{"name":"Paris Brain Institute CNRS UMR 7225 INSERM 1127 Sorbonne University  Paris France"},{"name":"LabCom Brain e\u2010Novation Paris Brain Institute  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Skrzatek","sequence":"additional","affiliation":[{"name":"Paris Brain Institute CNRS UMR 7225 INSERM 1127 Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eline","family":"Zeeboer","sequence":"additional","affiliation":[{"name":"Donders Institute for Brain, Cognition, and Behavior and Department of Neurology Center of Expertise for Parkinson and Movement Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Olivier","sequence":"additional","affiliation":[{"name":"Paris Brain Institute CNRS UMR 7225 INSERM 1127 Sorbonne University  Paris France"},{"name":"PANAM core facility INSERM 1127 Paris Brain Institute  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Christophe","family":"Corvol","sequence":"additional","affiliation":[{"name":"Paris Brain Institute CNRS UMR 7225 INSERM 1127 Sorbonne University  Paris France"},{"name":"Clinical Investigation Center Assistance Publique H\u00f4pitaux de Paris  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Foulon","sequence":"additional","affiliation":[{"name":"LabCom Brain e\u2010Novation Paris Brain Institute  Paris France"},{"name":"GENIOUS Healthcare  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9nica Z.","family":"Pastor","sequence":"additional","affiliation":[{"name":"Biostatistics Department CHU de Montpellier  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregoire","family":"Mercier","sequence":"additional","affiliation":[{"name":"Biostatistics Department CHU de Montpellier  Montpellier France"},{"name":"IDESP UA11 Universit\u00e9 de Montpellier INSERM  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Lau","sequence":"additional","affiliation":[{"name":"Paris Brain Institute CNRS UMR 7225 INSERM 1127 Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastiaan R.","family":"Bloem","sequence":"additional","affiliation":[{"name":"Donders Institute for Brain, Cognition, and Behavior and Department of Neurology Center of Expertise for Parkinson and Movement Radboud 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