{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:01:40Z","timestamp":1789538500620,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Little is known about the comparative effects of migraine preventive drugs. We aimed to estimate treatment retention and effectiveness of migraine preventive drugs in a nationwide registry\u2010based cohort study in Norway between 2010 and 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We assessed retention, defined as the number of uninterrupted treatment days, and effectiveness, defined as the reduction in filled triptan prescriptions during four 90\u2010day periods after the first preventive prescription, compared to a 90\u2010day baseline period. We compared retention and efficacy for different drugs against beta blockers. Comparative retention was estimated with hazard ratios (HRs), adjusted for covariates, using Cox regression, and effectiveness as odds ratios (ORs) using logistic regression, with propensity\u2010weighted adjustment for covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 104,072 migraine patients, 81,890 of whom were female (78.69%) and whose mean (standard deviation) age was 44.60 (15.61) years. Compared to beta blockers, botulinum toxin (HR\u20090.43, 95% confidence interval [CI] 0.42\u20130.44) and calcitonin gene\u2010related peptide pathway antibodies (CGRPabs; HR\u20090.63, 95% CI 0.59\u20130.66) were the least likely to be discontinued, while clonidine (HR\u20092.95, 95% CI 2.88\u20133.02) and topiramate (HR\u20091.34, 95% CI 1.31\u20131.37) were the most likely to be discontinued. Patients on simvastatin, CGRPabs, and amitriptyline were more likely to achieve a clinically significant reduction in triptan use during the first 90\u2009days of treatment, with propensity score\u2010adjusted ORs of 1.28 (95% CI 1.19\u20131.38), 1.23 (95% CI 0.79\u20131.90), and 1.13 (95% CI 1.08\u20131.17), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found a favorable effect of CGRPabs, amitriptyline, and simvastatin compared with beta blockers, while topiramate and clonidine were associated with poorer outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16062","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T09:02:10Z","timestamp":1695805330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparative retention and effectiveness of migraine preventive treatments: A nationwide registry\u2010based cohort study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5745-1094","authenticated-orcid":false,"given":"Marte H.","family":"Bj\u00f8rk","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine University of Bergen  Bergen Norway"},{"name":"Department of Neurology Haukeland University Hospital  Bergen Norway"},{"name":"NorHEAD, Norwegian Headache Research Centre Norwegian University of Science and Technology  Trondheim Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2562-2431","authenticated-orcid":false,"given":"Solveig","family":"Borkenhagen","sequence":"additional","affiliation":[{"name":"Oslo Economics  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3747-9786","authenticated-orcid":false,"given":"Francisco","family":"Oteiza","sequence":"additional","affiliation":[{"name":"Oslo Economics  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aud N.","family":"Dueland","sequence":"additional","affiliation":[{"name":"Sandvika Nevrosenter  Sandvika Norway"},{"name":"Department of Neurology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank E.","family":"S\u00f8rgaard","sequence":"additional","affiliation":[{"name":"Novartis Norge AS  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik Magnus","family":"S\u00e6ther","sequence":"additional","affiliation":[{"name":"Oslo Economics  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0766-2870","authenticated-orcid":false,"given":"Christoffer","family":"Bugge","sequence":"additional","affiliation":[{"name":"Oslo Economics  Oslo Norway"},{"name":"Department of Health Management and Health Economics University of Oslo  Oslo 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