{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:35:31Z","timestamp":1790796931512,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>The aim was to evaluate the effect of anti\u2010calcitonin gene related peptide (CGRP) (ligand or receptor) antibodies on depressive symptoms in subjects with migraine and to determine whether depressive symptoms predict treatment response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with migraine treated with erenumab and fremanezumab at the Leiden Headache Centre completed daily E\u2010headache diaries. A control group was included. Depressive symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS) and the Center for Epidemiological Studies Depression Scale (CES\u2010D) questionnaires at baseline (T0) and after 3\u2009months (T1). First, the effect of treatment on the reduction in HADS\u2010D and CES\u2010D scores was assessed, with reduction in depression scores as the dependent variable and reduction in monthly migraine days (MMD) and treatment with anti\u2010CGRP medication as independent variables. Second, depression as a predictor of treatment response was investigated, using the absolute reduction in MMD as a dependent variable and age, gender, MMD, active depression, impact, stress and locus of control scores as independent variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, <jats:italic>n<\/jats:italic>\u2009=\u2009108 patients were treated with erenumab, <jats:italic>n<\/jats:italic>\u2009=\u200990 with fremanezumab and <jats:italic>n<\/jats:italic>\u2009=\u200968 were without active treatment. Treatment with anti\u2010CGRP medication was positively associated with a reduction in the HADS\u2010D (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20091.65, <jats:italic>p<\/jats:italic>\u2009=\u20090.01) compared to control, independent of MMD reduction. However, the same effect was not found for the CES\u2010D (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20092.15, <jats:italic>p<\/jats:italic>\u2009=\u20090.21). Active depression predicted poorer response to erenumab (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) but not to fremanezumab (<jats:italic>p<\/jats:italic>\u2009=\u20090.09).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010CGRP (ligand or receptor) monoclonals lead to improvement of depressive symptoms in individuals with migraine, independent of migraine reduction. Depression may predict treatment response to erenumab but not to fremanezumab.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16106","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T14:25:49Z","timestamp":1697552749000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Depression and treatment with anti\u2010calcitonin gene related peptide (<scp>CGRP)<\/scp> (ligand or receptor) antibodies for migraine"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0089-8773","authenticated-orcid":false,"given":"Simone","family":"de Vries\u00a0Lentsch","sequence":"first","affiliation":[{"name":"Department of Neurology Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britt W. 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