{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:22:14Z","timestamp":1791015734925,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T00:00:00Z","timestamp":1698364800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009553","name":"Agentura Pro Zdravotnick\u00fd V\u00fdzkum \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The known impairments of the cardiovascular system in Parkinson\u00b4s disease (PD) are caused by autonomic dysfunction and manifested mainly in postural hypotension, chronotropic insufficiency, and reduced heart rate variability. Other dysfunctions, mainly stress response, arrhythmia occurrence, and heart morphology changes, are still the subject of research.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the heart rate and blood pressure reaction during exercise, advanced measurements of heart volumes and mass using cardiac magnetic resonance (CMR), and occurrence of arrhythmias in PD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty PD patients (19 men, mean age 57.5\u2009years) without known cardiac comorbidities underwent bicycle ergometry, electrocardiogram Holter monitoring and CMR. Exercise and CMR parameters were compared with controls (24 subjects for ergometry, 20 for CMR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PD patients had lower baseline systolic blood pressure (SBP) (117.8 vs. 128.3\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), peak SBP (155.8 vs. 170.8\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), and lower heart rate increase (49.7 vs. 64.3 beats per minute, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). PD patients had higher indexed left and right ventricular end\u2010diastolic volumes (68.5 vs. 57.3, <jats:italic>p<\/jats:italic>\u2009=\u20090.003 and 73.5 vs. 61.0\u2009mL\/m<jats:sup>2<\/jats:sup>, respectively) and also indexed left and right ventricular end\u2010systolic volumes (44.1 vs. 39.0, <jats:italic>p<\/jats:italic>\u2009=\u20090.013 and 29.0 vs. 22.0\u2009mL\/m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009=\u20090.013, respectively). A high prevalence of atrial fibrillation (8 subjects, 26.7%) was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This novel study combining functional and structural approaches showed that PD is linked with weaker blood pressure and heart rate reaction during exercise, increased myocardial mass and heart volumes compared to controls, and a high prevalence of atrial fibrillation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16110","type":"journal-article","created":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T17:16:46Z","timestamp":1698427006000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Parkinson\u00b4s disease cardiovascular symptoms: A new complex functional and structural insight"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4513-7388","authenticated-orcid":false,"given":"Vladim\u00edr","family":"Kincl","sequence":"first","affiliation":[{"name":"International Clinical Research Center, St. Anne 's University Hospital, Faculty of Medicine Masaryk University  Brno Czech Republic"},{"name":"Department of Internal Medicine\/Cardiology, St. Anne 's University Hospital, Faculty of Medicine Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-132X","authenticated-orcid":false,"given":"Roman","family":"Panovsk\u00fd","sequence":"additional","affiliation":[{"name":"International Clinical Research Center, St. Anne 's University Hospital, Faculty of Medicine Masaryk University  Brno Czech Republic"},{"name":"Department of Internal Medicine\/Cardiology, St. Anne 's University Hospital, Faculty of Medicine Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2691-9122","authenticated-orcid":false,"given":"Martina","family":"Bo\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Neurology St. Anne 's University Hospital, Masaryk University  Brno Czech Republic"},{"name":"Central European Institute of Technology  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9635-7404","authenticated-orcid":false,"given":"Ivan","family":"Rektor","sequence":"additional","affiliation":[{"name":"Department of Neurology St. Anne 's University Hospital, Masaryk University  Brno Czech Republic"},{"name":"Central European Institute of Technology  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9827-1006","authenticated-orcid":false,"given":"Mary Luz","family":"Mojica\u2010Pisciotti","sequence":"additional","affiliation":[{"name":"International Clinical Research Center, St. Anne 's University Hospital, Faculty of Medicine Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8292-3145","authenticated-orcid":false,"given":"Jan","family":"M\u00e1chal","sequence":"additional","affiliation":[{"name":"International Clinical Research Center, St. Anne 's University Hospital, Faculty of Medicine Masaryk University  Brno Czech Republic"},{"name":"Department of Pathological Physiology, Faculty of Medicine Masaryk University  Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70471-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM2003ra020003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2016.06.012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2013-000741"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27344"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439022"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.09.036"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-199906000-00001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/76.1.34"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2014.131"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2018.04.009"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0245353"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22612"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000250939.71343.7c"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439022"},{"key":"e_1_2_10_17_1","first-page":"443","article-title":"Nakamura S. 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