{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:22Z","timestamp":1787014162826,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Elevation of serum creatine kinase (CK) or hyperCKemia is considered a biological marker of myopathies. However, selective elevation of serum aldolase with normal CK has been reported in a few myopathies, including dermatomyositis, immune\u2010mediated myopathy with perimysial pathology and fasciitis with associated myopathy. The aim was to investigate the disease spectrum of myopathies with isolated aldolase elevation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical records were reviewed to identify patients &gt;18\u2009years old seen between December 1994 and June 2020 who had pathologically proven myopathies with elevated aldolase and normal CK level. Patients with alternative causes of aldolase elevation were excluded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010four patients with various types of myopathies were identified. Myopathies were treatable in 27 patients. The three most common etiologies were dermatomyositis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20098), overlap myositis (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094) and nonspecific myopathy (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20094). Perimysial pathology comprising inflammation, fragmentation, vasculitis, calcified perimysial vessels or extracellular amyloid deposition was found in 17\/34 patients (50%). Eight dermatomyositis patients with selective elevated aldolase were compared to 24 sex\u2010 and age\u2010matched patients with dermatomyositis and hyperCKemia. Dermatomyositis patients with normal CK significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) had less frequent cutaneous involvement (50.0% vs. 100.0%) and fibrillation potentials (50.0% vs. 90.5%) but higher median erythrocyte sedimentation rate (33.5 vs. 13.5\u2009mm\/h) and more common perifascicular mitochondrial pathology (37.5% vs. 4.2%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Isolated aldolase elevation can be found in a greater variety of myopathies than initially thought and most were treatable. Dermatomyositis is the most common myopathy with selective elevation of aldolase in our cohort, which features some unique characteristics compared to dermatomyositis with hyperCKemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16117","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T17:01:36Z","timestamp":1699030896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Disease spectrum of myopathies with elevated aldolase and normal creatine kinase"],"prefix":"10.1111","volume":"31","author":[{"given":"Pannathat","family":"Soontrapa","sequence":"first","affiliation":[{"name":"Department of Neurology, Division of Neuromuscular Medicine Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Medicine, Division of Neurology, Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3585-1687","authenticated-orcid":false,"given":"Shelly","family":"Shahar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neuromuscular Medicine Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Neurology Rambam Health Care Campus  Haifa Israel"},{"name":"Bruce Rappaport Faculty of Medicine Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lattawat","family":"Eauchai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neuromuscular Medicine Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Anatomy, Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floranne C.","family":"Ernste","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Rheumatology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0212-5697","authenticated-orcid":false,"given":"Teerin","family":"Liewluck","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Neuromuscular Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.155358"},{"key":"e_1_2_8_3_1","first-page":"117","article-title":"Aldolase","volume":"116","author":"Taguchi K","year":"2001","journal-title":"Rinsho Byori"},{"issue":"6","key":"e_1_2_8_4_1","first-page":"815","article-title":"Clinical applications of muscle enzymes and proteins","volume":"4","author":"Wu AH","year":"1992","journal-title":"Curr Opin 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