{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:37:32Z","timestamp":1790008652622,"version":"4.0.1"},"reference-count":49,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Deep brain stimulation (DBS) has emerged as a promising treatment for movement disorders. This prospective study aims to evaluate the effects of bilateral subthalamic nucleus DBS (STN\u2010DBS) on motor and non\u2010motor symptoms in patients with primary Meige syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty patients who underwent bilateral STN\u2010DBS between April 2017 and June 2020 were included. Standardized and validated scales were utilized to assess the severity of dystonia, health\u2010related quality of life, sleep, cognitive function and mental status at baseline and at 1\u2009year and 3\u2009years after neurostimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The Burke\u2212Fahn\u2212Marsden Dystonia Rating Scale movement scores showed a mean improvement of 63.0% and 66.8% at 1\u2009year and 3\u2009years, respectively, after neurostimulation. Similarly, the Burke\u2212Fahn\u2212Marsden Dystonia Rating Scale disability scores improved by 60.8% and 63.3% at the same time points. Postoperative quality of life demonstrated a significant and sustained improvement throughout the follow\u2010up period. However, cognitive function, mental status, sleep quality and other neuropsychological functions did not change after 3\u2009years of neurostimulation. Eight adverse events occurred in six patients, but no deaths or permanent sequelae were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Bilateral STN\u2010DBS is a safe and effective alternative treatment for primary Meige syndrome, leading to improvements in motor function and quality of life. Nevertheless, it did not yield significant amelioration in cognitive, mental, sleep status and other neuropsychological functions after 3\u2009years of neurostimulation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16121","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T08:35:27Z","timestamp":1699346127000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Subthalamic nucleus deep brain stimulation in primary Meige syndrome: motor and non\u2010motor outcomes"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2234-976X","authenticated-orcid":false,"given":"Qing\u2010Pei","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Peking University People's Hospital  Beijing 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