{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T06:40:52Z","timestamp":1781332852281,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T00:00:00Z","timestamp":1698969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Despite their detrimental impact on the quality of life in autoimmune encephalitis, sleep disorders have not been investigated in anti\u2010glutamic acid decarboxylase (GAD65) associated neurological syndromes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six consecutive adult patients diagnosed with anti\u2010GAD65\u2010associated neurological syndromes (four with limbic encephalitis and two with stiff\u2010person syndrome) and 12 healthy controls were enrolled. Participants underwent sleep interviews and sleep studies including night\u2010time video\u2010polysomnography, followed by five daytime multiple sleep latency tests (MSLTs, to assess propensity to fall asleep) and an 18 h bed rest polysomnography (to assess excessive sleep need).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients reported the need for daily naps and that their cognition and quality of life were altered by sleepiness, but they had normal scores on the Epworth sleepiness scale. Compared with controls, sleep latencies during the MSLT were shorter in the patient group (median 5.8 min, interquartile range [IQR] 4.5, 6.0 vs. 17.7 min, IQR 16.3, 19.7, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), and the arousal index was reduced (2.5\/h, IQR 2.3, 3.0 vs. 22.3\/h, IQR 13.8, 30.0, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), although total sleep time was similar between groups (621 min, IQR 464, 651 vs. 542.5 min, IQR 499, 582, <jats:italic>p<\/jats:italic>\u2009=\u20090.51). Remarkably, all six patients had MSLT latencies \u22648\u2009min, indicating severe sleepiness. No parasomnia or sleep\u2010disordered breathing was detected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Central hypersomnia is a relevant characteristic of anti\u2010GAD65\u2010associated neurological syndromes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16125","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T21:01:10Z","timestamp":1699045270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypersomnia in anti\u2010glutamic acid decarboxylase 65 (<scp>GAD65<\/scp>) associated neurological syndromes: A pilot study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6888-3311","authenticated-orcid":false,"given":"Lina","family":"Jeantin","sequence":"first","affiliation":[{"name":"Sleep Disorders Unit, R3S Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9431-0581","authenticated-orcid":false,"given":"Ana","family":"Gales","sequence":"additional","affiliation":[{"name":"Sleep Disorders Unit, R3S Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Berzero","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Unit, Neurology Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smaranda","family":"Leu","sequence":"additional","affiliation":[{"name":"Sleep Disorders Unit, R3S Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9my","family":"Proust","sequence":"additional","affiliation":[{"name":"Sleep Disorders Unit, R3S Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Giry","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Unit, Neurology Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nefeli Eirini","family":"Valyraki","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Unit, Neurology Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Birzu","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Unit, Neurology Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agusti","family":"Alentorn","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Unit, Neurology Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Vidailhet","sequence":"additional","affiliation":[{"name":"Movement Disorder Unit, Neurology Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitri","family":"Psimaras","sequence":"additional","affiliation":[{"name":"Neuro\u2010Oncology Unit, Neurology Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Arnulf","sequence":"additional","affiliation":[{"name":"Sleep Disorders Unit, R3S Department Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital, AP\u2010HP Sorbonne University  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00401-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-021-01020-x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0463-z"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30341-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn183"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.6.753"},{"key":"e_1_2_10_8_1","unstructured":"American Academy of Sleep Medicine.The AASM Manual for the Scoring of Sleep and Associated Events: Rules Terminology and Technical Specifications. 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