{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:53:21Z","timestamp":1791089601041,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100024075","name":"Region Syddanmark","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024075","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006356","name":"Syddansk Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Hereditary haemorrhagic telangiectasia (HHT) is a genetic disease with fragile blood vessels and vascular malformations, potentially causing neurological manifestations, including stroke and cerebral abscesses. The study aimed to investigate neurological manifestations in the Danish HHT database, focusing on pulmonary arteriovenous malformations (PAVMs) as a risk factor for cerebral events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective analysis of the Danish HHT database was conducted, cross\u2010referencing neurological outcomes with the Danish Apoplexy Register for accuracy. Patients were stratified by HHT type. Primary outcomes included ischaemic stroke, transient ischaemic attack and cerebral haemorrhage. Secondary outcomes comprised age, age at HHT diagnosis, age at cerebral ischaemic event, and PAVM and cerebral arteriovenous malformation status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six hundred and sixty\u2010four HHT patients were included. PAVM was diagnosed in 54% of patients, with higher prevalence in HHT type 1 (70%) compared to HHT type 2 (34%) and juvenile polyposis HHT (66%). Ischaemic stroke or transient ischaemic attack occurred in 12.5%, with a higher risk associated with macroscopic PAVM. Logistic regression showed a nearly 10 times increased risk of ischaemic stroke with macroscopic PAVM. Cerebral abscesses occurred in 3.2% of patients, all with macroscopic PAVM. Incomplete PAVM closure increased cerebral abscess risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study provides valuable insights into the prevalence of neurological manifestations and vascular events in HHT patients. The presence of PAVM was associated with an increased risk of ischaemic stroke, highlighting the importance of early screening and intervention. The findings emphasize the need for comprehensive management strategies targeting both vascular and neurological complications in HHT patients, especially regarding secondary stroke prevention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16128","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T09:40:12Z","timestamp":1699868412000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High risk of ischaemic stroke amongst patients with hereditary haemorrhagic telangiectasia"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6819-4345","authenticated-orcid":false,"given":"Mikkel Seremet","family":"Kofoed","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Odense University Hospital, Clinical Institute University of Southern Denmark  Odense Denmark"},{"name":"BRIDGE (Brain Research\u2014Inter Disciplinary Guided Excellence) University of Southern Denmark  Odense Denmark"},{"name":"Department of Ear, Nose and Throat Surgery, Odense University Hospital, Clinical Institute University of Southern Denmark  Odense Denmark"},{"name":"University of Southern Denmark (SDU)  Odense Denmark"},{"name":"OPEN Region of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pernille M.","family":"T\u00f8rring","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Odense University Hospital  Odense Denmark"},{"name":"VASCERN HHT Reference Center Odense Universitetshospital, Syddansk Universitet  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex Alban","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Odense University Hospital, Clinical Institute University of Southern Denmark  Odense 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Hospital, Clinical Institute University of Southern Denmark  Odense Denmark"},{"name":"BRIDGE (Brain Research\u2014Inter Disciplinary Guided Excellence) University of Southern Denmark  Odense Denmark"},{"name":"University of Southern Denmark (SDU)  Odense Denmark"},{"name":"OPEN Region of Southern Denmark  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.00398.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.16320"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0b013e31802f8da1"},{"key":"e_1_2_12_5_1","first-page":"1","article-title":"Neurologic complications in hereditary hemorrhagic telangiectasia with pulmonary arteriovenous malformations: a systematic review","volume":"50","author":"Agarwal J","year":"2022","journal-title":"Can J Neurol 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