{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:25:56Z","timestamp":1783527956068,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Quantification of neurofilament light chain protein in serum (sNfL) enables the neuro\u2010axonal damage in peripheral blood to be reliably assessed and monitored. There is a long\u2010standing debate whether essential tremor represents a \u2018benign\u2019 tremor syndrome or whether it is linked to neurodegeneration. This study aims to investigate sNfL concentrations in essential tremor compared to healthy controls (cross\u2010sectionally and longitudinally) and to assess whether sNfL is associated with motor and nonmotor markers of disease progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of patients with essential tremor from our prospective registry on movement disorders (PROMOVE) were retrospectively analysed. Age\u2010, sex\u2010 and body\u2010mass\u2010index\u2010matched healthy controls were recruited from an ongoing community\u2010dwelling aging cohort. sNfL was quantified by an ultra\u2010sensitive single molecule array (Simoa). All participants underwent detailed clinical examination at baseline and after approximately 5\u2009years of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010seven patients with clinically diagnosed essential tremor were included and 37 controls. The essential tremor group showed significantly higher sNfL levels compared to healthy controls at baseline and follow\u2010up. sNfL levels increased over time in both groups, and the slope of sNfL increase was similar in the essential tremor and healthy control groups. Comparing patients with a disease duration under 5\u2009years to those with a longer disease duration, the former group had a significantly greater increase of sNfL over time, which strongly correlated to worsening of tremor and cognition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that neurodegeneration, possibly happening at an early disease stage, might play a role in the pathophysiology of essential tremor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16143","type":"journal-article","created":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T03:53:03Z","timestamp":1700279583000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Elevated serum neurofilament light chain protein in patients with essential 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