{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:03:15Z","timestamp":1791507795241,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Neurological disorders constitute a significant portion of the global disease burden, affecting &gt;30% of the world's population. This prevalence poses a substantial threat to global health in the foreseeable future. A lack of awareness regarding this high burden of neurological diseases has led to their underrecognition, underappreciation, and insufficient funding. Establishing a strategic and comprehensive research agenda for brain\u2010related studies is a crucial step towards aligning research objectives among all pertinent stakeholders and fostering greater societal awareness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A scoping literature review was undertaken by a working group from the European Academy of Neurology (EAN) to identify any existing research agendas relevant to neurology. Additionally, a specialized survey was conducted among all EAN scientific panels, including neurologists and patients, inquiring about their perspectives on the current research priorities and gaps in neurology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The review revealed the absence of a unified, overarching brain research agenda. Existing research agendas predominantly focus on specialized topics within neurology, resulting in an imbalance in the number of agendas across subspecialties. The survey indicated a prioritization of neurological disorders and research gaps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Building upon the findings from the review and survey, key components for a strategic and comprehensive neurological research agenda in Europe were delineated. This research agenda serves as a valuable prioritization tool for neuroscientific researchers, as well as for clinicians, donors, and funding agencies in the field of neurology. It offers essential guidance for creating a roadmap for research and clinical advancement, ultimately leading to heightened awareness and reduced burden of neurological disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16171","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T01:29:21Z","timestamp":1702430961000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A strategic neurological research agenda for Europe: Towards clinically relevant and patient\u2010centred neurological research priorities"],"prefix":"10.1111","volume":"31","author":[{"given":"Paul","family":"Boon","sequence":"first","affiliation":[{"name":"Department of Neurology and 4Brain Ghent University Hospital  Ghent Belgium"},{"name":"Eindhoven University of Technology  Eindhoven the Netherlands"},{"name":"European Academy of Neurology  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6844-5514","authenticated-orcid":false,"given":"Emma","family":"Lescrauwaet","sequence":"additional","affiliation":[{"name":"Department of Neurology and 4Brain Ghent University Hospital  Ghent Belgium"},{"name":"Eindhoven University of Technology  Eindhoven the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2372-4453","authenticated-orcid":false,"given":"Katina","family":"Aleksovska","sequence":"additional","affiliation":[{"name":"European Academy of Neurology  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Konti","sequence":"additional","affiliation":[{"name":"European Academy of Neurology  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Neurology and Comprehensive Centre of Clinical Neurosciences and Mental Health Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Leonardi","sequence":"additional","affiliation":[{"name":"Neurology, Public Health, Disability Unit and Coma Research Centre Fondazione IRCCS Instituto Neurologico C. Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Marson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics University of Liverpool  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1975-6919","authenticated-orcid":false,"given":"Ulf","family":"Kallweit","sequence":"additional","affiliation":[{"name":"Centre for Narcolepsy and Hypersomnolence Disorders, Professorship for Narcolepsy and Hypersomnolence Research, Department of Medicine Witten\/Herdecke University  Witten Germany"},{"name":"Centre for Biomedical Education and Research Witten\/Herdecke University  Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7968-5908","authenticated-orcid":false,"given":"Elena","family":"Moro","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Neurology and Neurological Rehabilitation of CHU  Grenoble France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Toscano","sequence":"additional","affiliation":[{"name":"ERN\u2010NMD Centre for Neuromuscular Disorders of Messina, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5455-4573","authenticated-orcid":false,"given":"Irena","family":"Rektorova","sequence":"additional","affiliation":[{"name":"Brain and Mind Research Central European Institute of Technology, Masaryk University  Brno Czechia"},{"name":"First Department of Neurology St. Anne's University Hospital and Faculty of Medicine, Masaryk University  Brno Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Crean","sequence":"additional","affiliation":[{"name":"European Academy of Neurology  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Sander","sequence":"additional","affiliation":[{"name":"European Academy of Neurology  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-0804","authenticated-orcid":false,"given":"Robert","family":"Joyce","sequence":"additional","affiliation":[{"name":"Discipline of Occupational Therapy, School of Health Sciences National University of Ireland  Galway Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4535-0245","authenticated-orcid":false,"given":"Claudio","family":"Bassetti","sequence":"additional","affiliation":[{"name":"Department of Neurology, Inselspital University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-02001-z"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30411-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2011.08.008"},{"key":"e_1_2_9_5_1","unstructured":"The Economist Impact.The value of action: mitigating the global impact of neurological disorders.2022."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f4766"},{"key":"e_1_2_9_7_1","unstructured":"World Health Assembly.Intersectoral global action plan on epilepsy and other neurological disorders.2021."},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40309-021-00177-0"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40900-015-0003-x"},{"key":"e_1_2_9_10_1","unstructured":"The Shared European Brain Research Agenda.The European brain research area.https:\/\/www.ebra.eu\/sebra\/. Accessed June 1 2023."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15391"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(20)30190-0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118445112.stat06537"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12781"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40900-018-0089-z"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/2396987318808719"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30415-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00044-8"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516687404"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004977"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221075990"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852920002084"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200911"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.1783"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-212922"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2021.0216"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1471301218816250"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2022.108673"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-019-00767-8"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2018.02.015"},{"key":"e_1_2_9_31_1","unstructured":"British Paediatric Neurology Association.Childhood neurological conditions | James Lind Alliance. 2022. Accessed February 8 2023.https:\/\/www.jla.nihr.ac.uk\/priority\u2010setting\u2010partnerships\/childhood\u2010neurological\u2010conditions\/"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.5871"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102623"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/02687038.2021.1957081"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/21641846.2022.2124775"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00120-5"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.nt.0000905788.76255.4d"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.16171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T09:44:11Z","timestamp":1710755051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.16171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,12]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/ene.16171"],"URL":"https:\/\/doi.org\/10.1111\/ene.16171","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,12]]},"assertion":[{"value":"2023-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16171"}}