{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:44:37Z","timestamp":1772160277849,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>White matter lesions (WMLs) are frequent in sickle cell disease (SCD), with a prevalence described to be as high as 53% by age 30. Cerebrovascular regulation and cardiovascular autonomic regulation, more specifically the sympatho\u2010vagal balance, can be altered in SCD. In this study the association between WMLs, cerebrovascular regulation and sympatho\u2010vagal balance was assessed in SCD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and results<\/jats:title>\n                    <jats:p>\n                      Sickle cell disease patients with no history of stroke were prospectively evaluated for cerebrovascular reactivity using the breath\u2010holding test (BHT), the sympatho\u2010vagal balance (ratio low frequency\/high frequency [HF]) using heart rate variability parameters and cerebral autoregulation in the time domain using correlation index Mx, and arterial cerebral compliance based on continuous assessment of cerebral blood flow velocities using transcranial Doppler ultrasound and arterial blood pressure with photo\u2010plethysmography. WMLs were assessed with magnetic resonance imaging using Fazekas score grading and the presence of lacunes. Forty\u2010one patients (F\/M 25\/16) were included. Median age was 37.5\u2009years (19\u201365). Twenty\u2010nine (70.7%) patients had SS genotype. Eleven patients had WMLs (26.8%). Patients with WMLs were significantly older (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), had a lower HF (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.005) and an impaired cerebral arterial compliance (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.014). The receiver operating curve for the regression model including age and HF showed a higher area under the curve compared to age alone (0.946 vs. 0.876). BHT and Mx did not significantly differ between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lower parasympathetic activity and impaired cerebral arterial compliance were associated with WMLs in adults with SCD. This could potentially yield to a better understanding of pathophysiological parameters leading to premature cerebrovascular ageing in SCD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16183","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T11:29:27Z","timestamp":1704194967000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cerebrovascular and cardiovascular autonomic regulation in sickle cell patients with white matter lesions"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5716-2819","authenticated-orcid":false,"given":"Christophe","family":"Ferreira\u00a0De\u00a0Matos","sequence":"first","affiliation":[{"name":"Internal Medicine Department\u2014IUCT Oncopole  Toulouse 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