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In the INTERSTROKE study, the association of pre\u2010morbid sleep disturbance with stroke severity and functional outcome following stroke was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      INTERSTROKE is an international case\u2013control study of first acute stroke. This analysis included cases who completed a standardized questionnaire concerning nine symptoms of sleep disturbance (sleep onset latency, duration, quality, nocturnal awakening, napping duration, whether a nap was planned, snoring, snorting and breathing cessation) in the month prior to stroke (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20092361). Two indices were derived representing sleep disturbance (range 0\u20139) and obstructive sleep apnoea (range 0\u20133) symptoms. Logistic regression was used to estimate the magnitude of association between symptoms and stroke severity defined by the modified Rankin Score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean age of participants was 62.9\u2009years, and 42% were female. On multivariable analysis, there was a graded association between increasing number of sleep disturbance symptoms and initially severe stroke (2\u20133, odds ratio [OR] 1.44, 95% confidence interval [CI] 1.07\u20131.94; 4\u20135, OR 1.66, 95% CI 1.23\u20132.25; &gt;5, OR 2.58, 95% CI 1.83\u20133.66). Having &gt;5 sleep disturbance symptoms was associated with significantly increased odds of functional deterioration at 1 month (OR 1.54, 95% CI 1.01\u20132.34). A higher obstructive sleep apnoea score was also associated with significantly increased odds of initially severe stroke (2\u20133, OR 1.48; 95% CI 1.20\u20131.83) but not functional deterioration at 1 month (OR 1.19, 95% CI 0.93\u20131.52).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sleep disturbance symptoms were common and associated with an increased odds of severe stroke and functional deterioration. Interventions to modify sleep disturbance may help prevent disabling stroke\/improve functional outcomes and should be the subject of future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16193","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:45:45Z","timestamp":1711500345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pre\u2010morbid sleep disturbance and its association with stroke severity: results from the international\n                    <scp>INTERSTROKE<\/scp>\n                    study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8703-0661","authenticated-orcid":false,"given":"Christine E.","family":"Mc\u00a0Carthy","sequence":"first","affiliation":[{"name":"HRB Clinical Research Facility University of Galway  Galway 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Oveis","family":"Gharan","sequence":"additional","affiliation":[{"name":"Rush Alzheimer Disease Centre Rush University Medical Centre  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albertino","family":"Damasceno","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Eduardo Mondlane University  Maputo Mozambique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle Klingenberg","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Neurology Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Rosengren","sequence":"additional","affiliation":[{"name":"Molecular and Clinical Medicine Gothenburg University  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Okechukwu","family":"Ogah","sequence":"additional","affiliation":[{"name":"Cardiology Unit, Department of Medicine, 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