{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T12:25:15Z","timestamp":1784982315398,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM21\/00178"],"award-info":[{"award-number":["CM21\/00178"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR23\/00005"],"award-info":[{"award-number":["JR23\/00005"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>According to the latest European guidelines, discontinuation of monoclonal antibodies against calcitonin gene\u2010related peptide (anti\u2010CGRP MAb) may be considered after 12\u201318\u2009months of treatment. However, some patients may worsen after discontinuation. In this study, we assessed the response following treatment resumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective study conducted in 14 Headache Units in Spain. We included patients with response to anti\u2010CGRP MAb with clinical worsening after withdrawal and resumption of treatment. Numbers of monthly migraine days (MMD) and monthly headache days (MHD) were obtained at four time points: before starting anti\u2010CGRP MAb (T\u2010baseline); last month of first treatment period (T\u2010suspension); month of restart due to worsening (T\u2010worsening); and 3\u2009months after resumption (T\u2010reintroduction). The response rate to resumption was calculated. Possible differences among periods were analysed according to MMD and MHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 360 patients, 82% women, with a median (interquartile range [IQR]) age at migraine onset of 18\u2009(12) years. The median (IQR) MHD at T\u2010baseline was 20 (13) and MMD was 5 (6); at T\u2010suspension, the median (IQR) MHD was 5 (6) and MMD was 4 (5); at T\u2010worsening, the median (IQR) MHD was 16 (13) and MMD was 12 (6); and at T\u2010reintroduction, the median (IQR) MHD was 8 (8) and MHD was 5 (5). In the second period of treatment, a 50% response rate was achieved by 57.4% of patients in MHD and 65.8% in MMD. Multivariate models showed significant differences in MHD between the third month after reintroduction and last month before suspension of first treatment period (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest that anti\u2010CGRP MAb therapy is effective after reintroduction. However, 3\u2009months after resumption, one third of the sample reached the same improvement as after the first treatment period.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16203","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T13:38:53Z","timestamp":1706189933000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<scp>RE\u2010START<\/scp>: Exploring the effectiveness of anti\u2010calcitonin gene\u2010related peptide resumption after discontinuation in migraine"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0339-6616","authenticated-orcid":false,"given":"Celia","family":"Romero\u00a0del\u00a0Rinc\u00f3n","sequence":"first","affiliation":[{"name":"Department of Neurology, Hospital Universitario de La Princesa &amp; Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa) Universidad Aut\u00f3noma de Madrid (UAM)  Madrid 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