{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T20:28:21Z","timestamp":1773692901234,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T00:00:00Z","timestamp":1707264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Anti\u2010calcitonin gene\u2010related peptide (CGRP) therapies are recent preventive therapies approved for both episodic and chronic migraine. One of the measures of effectiveness is the withdrawal of other preventive treatments. The objective of this study is to quantify the impact of anti\u2010CGRP drugs in concomitant preventive treatment in patients with migraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was an observational, retrospective, multicenter cohort study with patients from nine national headache units. Patients with migraine undergoing treatment for at least 6\u2009months with anti\u2010CGRP antibodies, who were initially associated with some preventive treatment (oral and\/or onabotulinumtoxinA) were included. Demographic and clinical variables were collected, as well as variables related to headache. Differences according to withdrawal or nonwithdrawal were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 408 patients were included, 86.52% women, 48.79 (SD\u2009=\u20091.46) years old. Preventive treatment was withdrawn in 43.87% (179\/408), 20.83% partially and 23.04% totally. In 27.45% (112\/408), it was maintained exclusively due to comorbidity and in 28.6% (117\/408) due to partial efficacy. The most frequent time of withdrawal was between 3 and 5\u2009months after the start of treatment. The baseline characteristics associated with nonwithdrawal were comorbidities: insomnia, hypertension and obesity, chronic migraine, and medication overuse. In the multivariate analysis, the absence of high blood pressure, a greater number of preventive treatments at the start, and a lower number of migraine days\/month after anti\u2010CGRP treatment were independently associated with withdrawal of the treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anti\u2010CGRP antibodies allow the withdrawal of associated preventive treatment in a significant percentage of patients, which supports its effectiveness in real\u2010life conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16215","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T11:38:24Z","timestamp":1707305904000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluation of the concomitant use of prophylactic treatments in patients with migraine under <scp>anti\u2010calcitonin gene\u2010related peptide<\/scp> therapies: The <scp>PREVENAC<\/scp> study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0038-3406","authenticated-orcid":false,"given":"Ana Beatriz","family":"Gago\u2010Veiga","sequence":"first","affiliation":[{"name":"Headache Unit Hospital Universitario de la Princesa &amp; Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelia","family":"Lopez\u2010Alcaide","sequence":"additional","affiliation":[{"name":"Headache Unit Hospital Universitario de la Princesa &amp; Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010Princesa)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0622-8228","authenticated-orcid":false,"given":"Sonia","family":"Quintas","sequence":"additional","affiliation":[{"name":"Headache Unit Hospital Universitario de la Princesa 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