{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:25Z","timestamp":1787014165078,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Grant No 81600970"],"award-info":[{"award-number":["Grant No 81600970"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Clinical symptoms and laboratory indices for acute inflammatory demyelinating polyneuropathy (AIDP), a variant of Guillain\u2212Barr\u00e9 syndrome, and acute\u2010onset chronic inflammatory demyelinating polyneuropathy (A\u2010CIDP) were analyzed to identify factors that could contribute to early differential diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective chart review was performed on 44 AIDP and 44 A\u2010CIDP patients looking for any demographic characteristics, clinical manifestations or laboratory parameters that might differentiate AIDP from acutely presenting CIDP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In Guillain\u2212Barr\u00e9 syndrome patients (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200963), 69.84% (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200944) were classified as having AIDP, 19.05% (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200912) were found to have acute motor axonal neuropathy, 6.35% (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20094) were found to have acute motor and sensory axonal neuropathy, and 4.76% (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20093) were found to have Miller Fisher syndrome. Serum uric acid (UA) was higher in A\u2010CIDP patients (329.55\u2009\u00b1\u200972.23\u2009\u03bcmol\/L) than in AIDP patients (221.08\u2009\u00b1\u200971.32\u2009\u03bcmol\/L) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000). Receiver operating characteristic analyses indicated that the optimal UA cutoff was 283.50\u2009\u03bcmol\/L. Above this level, patients were more likely to present A\u2010CIDP than AIDP (specificity 81.80%, sensitivity 81.80%). During the follow\u2010up process, serum samples were effectively collected from 19 AIDP patients during the rehabilitation phase and 28 A\u2010CIDP patients during the remission stage, and it was found that UA levels were significantly increased in A\u2010CIDP (remission) (298.9\u2009\u00b1\u200990.39\u2009\u03bcmol\/L) compared with AIDP (rehabilitation) (220.1\u2009\u00b1\u2009108.2\u2009\u03bcmol\/L,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results suggest that serum UA level can help to differentiate AIDP from A\u2010CIDP with high specificity and sensitivity, which is helpful for early diagnosis and guidance of treatment.<\/jats:p>\n                  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