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This study aims (1) to describe treatment, functional abilities, respiratory and cardiac status during transition to adulthood and adult stages; and (2) to explore the association between glucocorticoid treatment after loss of ambulation (LOA) and late\u2010stage clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective single\u2010centre study on individuals with Duchenne muscular dystrophy (\u226516\u2009years old) between 1986 and 2022. Logistic regression, Cox proportional hazards models and survival analyses were conducted utilizing data from clinical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 112 individuals were included. Mean age was 23.4\u2009\u00b1\u20095.2\u2009years and mean follow\u2010up was 18.5\u2009\u00b1\u20095.5\u2009years. At last assessment, 47.2% were on glucocorticoids; the mean dose of prednisone was 0.38\u2009\u00b1\u20090.13 mg\/kg\/day and of deflazacort 0.43\u2009\u00b1\u20090.16\u2009mg\/kg\/day. At age 16\u2009years, motor function limitations included using a manual wheelchair (89.7%), standing (87.9%), transferring from a wheelchair (86.2%) and turning in bed (53.4%); 77.5% had a peak cough flow &lt;270\u2009L\/min, 53.3% a forced vital capacity percentage of predicted &lt;50% and 40.3% a left ventricular ejection fraction &lt;50%. Glucocorticoids after LOA reduced the risk and delayed the time to difficulties balancing in the wheelchair, loss of hand to mouth function, forced vital capacity percentage of predicted &lt;30% and forced vital capacity &lt;1\u2009L and were associated with lower frequency of left ventricular ejection fraction &lt;50%, without differences between prednisone and deflazacort. Glucocorticoid dose did not differ by functional, respiratory or cardiac status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Glucocorticoids after LOA preserve late\u2010stage functional abilities, respiratory and cardiac function. It is suggested using functional abilities, respiratory and cardiac status at transition stages for adult services planning.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ene.16267","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T06:30:10Z","timestamp":1711953010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Functional abilities, respiratory and cardiac function in a large cohort of adults with Duchenne muscular dystrophy treated with glucocorticoids"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2709-265X","authenticated-orcid":false,"given":"Marianela","family":"Schiava","sequence":"first","affiliation":[{"name":"John Walton Muscular Dystrophy Research Centre Newcastle University and Newcastle Hospitals NHS Foundation Trusts  Newcastle Upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert 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