{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:17:01Z","timestamp":1791951421644,"version":"4.3.4"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","award":["ARUK\u2010CRF2020A\u2010003"],"award-info":[{"award-number":["ARUK\u2010CRF2020A\u2010003"]}],"id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","award":["A1332"],"award-info":[{"award-number":["A1332"]}],"id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000833","name":"Rosetrees Trust","doi-asserted-by":"publisher","award":["PGL21\/10079"],"award-info":[{"award-number":["PGL21\/10079"]}],"id":[{"id":"10.13039\/501100000833","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["2016T86"],"award-info":[{"award-number":["2016T86"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Euro J of Neurology"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>An increasing number of cases of iatrogenic cerebral amyloid angiopathy (CAA) have now been reported worldwide. Proposed diagnostic criteria require a history of medical intervention with potential for amyloid\u2010\u03b2 transmission, for example those using cadaveric dura mater or requiring instrumentation of the brain or spinal cord. Clinical presentation occurs after an appropriate latency (usually three or four decades); to date, most patients with iatrogenic CAA have had \u2018early\u2010onset\u2019 disease (compared to sporadic, age\u2010related, CAA), as a consequence of childhood procedures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We describe five cases of possible iatrogenic CAA in adults presenting in later life (aged 65\u2009years and older); all had prior neurosurgical interventions and presented after a latency suggestive of iatrogenic disease (range 30\u201339\u2009years). Use of cadaveric dura mater was confirmed in one case, and highly likely in the remainder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The presentation of iatrogenic CAA in older adults widens the known potential spectrum of this disease and highlights the difficulties of making the diagnosis in this age group, and particularly in differentiating iatrogenic from sporadic CAA. Increased vigilance for cases presenting at an older age is essential for furthering our understanding of the clinical phenotype and broader implications of iatrogenic CAA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ene.16278","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T08:40:34Z","timestamp":1711010434000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Iatrogenic cerebral amyloid angiopathy in older adults"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7342-2488","authenticated-orcid":false,"given":"Larysa","family":"Panteleienko","sequence":"first","affiliation":[{"name":"Department of Brain Repair and Rehabilitation, Stroke Research Centre UCL Queen Square Institute of Neurology  London UK"},{"name":"Department of Neurology Bogomolets National Medical University  Kyiv Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7434-1201","authenticated-orcid":false,"given":"Dermot","family":"Mallon","sequence":"additional","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery, Queen Square University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupert","family":"Oliver","sequence":"additional","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery, Queen Square University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4441-3750","authenticated-orcid":false,"given":"Ahmed","family":"Toosy","sequence":"additional","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery, Queen Square University College London Hospitals NHS Foundation Trust  London UK"},{"name":"Department of Neuroinflammation UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Internal Medicine Saga University Faculty of Medicine  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Neurology Kansai Medical University  Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1429-6853","authenticated-orcid":false,"given":"Kanishk","family":"Kaushik","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Centre  Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6838-9521","authenticated-orcid":false,"given":"Marieke J. H.","family":"Wermer","sequence":"additional","affiliation":[{"name":"Department of Neurology Leiden University Medical Centre  Leiden The Netherlands"},{"name":"University Medical Centre Groningen  Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Hara","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Internal Medicine Saga University Faculty of Medicine  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3206-6939","authenticated-orcid":false,"given":"Yusuke","family":"Yakushiji","sequence":"additional","affiliation":[{"name":"Department of Neurology Kansai Medical University  Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0190-7782","authenticated-orcid":false,"given":"Gargi","family":"Banerjee","sequence":"additional","affiliation":[{"name":"National Hospital for Neurology and Neurosurgery, Queen Square University College London Hospitals NHS Foundation Trust  London UK"},{"name":"MRC Prion Unit at UCL Institute of Prion Diseases  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2074-1861","authenticated-orcid":false,"given":"David J.","family":"Werring","sequence":"additional","affiliation":[{"name":"Department of Brain Repair and Rehabilitation, Stroke Research Centre UCL Queen Square Institute of Neurology  London UK"},{"name":"National Hospital for Neurology and Neurosurgery, Queen Square University College London Hospitals NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25407"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2022-328792"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.041690"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-023-01528-7"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2023.2212394"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15997"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01352-1"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad193"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00208-3"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0197-4580(97)00056-0"}],"container-title":["European Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ene.16278","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T06:22:44Z","timestamp":1715149364000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ene.16278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,21]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/ene.16278"],"URL":"https:\/\/doi.org\/10.1111\/ene.16278","archive":["Portico"],"relation":{},"ISSN":["1351-5101","1468-1331"],"issn-type":[{"value":"1351-5101","type":"print"},{"value":"1468-1331","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,21]]},"assertion":[{"value":"2023-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e16278"}}